左乙拉西坦对伴中央颞区棘波的儿童良性癫痫脑活动影响的静息态功能磁共振成像评价

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Abstract Objective: To use amplitude of low frequence fluctuation(ALFF) to evaluate the brain functional change of benign childhood epilepsy with centro-temporal spikes(BECTS) and the influence of levetiracetam(LEV) on BECTS. Methods: Twenty-two BECTS treated with LEV, twenty-two BECTS with no treatment and twenty-two age and sex-matched healthy children were included to preform functional magnetic resonance imaging(fMRI). After data preprocessing, the difference of ALFF among the three groups was obtained by the analysis of variance, and their correlation with clinical index were reported. Results: Compared to the healthy group, the ALFF of bilateral Rolandic areas in both untreated group and the LEV group were increased. And compared to the non-treatment group, the ALFF of bilateral Rolandic areas in the LEV group were decreased. The ALFF of left precentral/postcentral gyrus and left inferior frontal gyrus showed positive correlation with the duration of untreated BECTS, while the left precentral gyrus and the right superior frontal gyrus showed negative correlation with the duration of the LEV effects and the left precuneus and right middle temporal gyrus showed a positive correlation with the duration of the LEV effects in LEV group. Conclusion: The discharge areas of BECTS in brain show increased activities, and LEV can effectively reduce the intrinsic brain activity in these areas of BECTS and impact on the areas about language, attention and default mode network(DMN). These evidences based on fMRI show that LEV is useful in the treatment of BECTS.

Key words： Epilepsy Child Magnetic resonance imaging

Received: 12 January 2017

PACS:	Ｒ742.1
	Ｒ445.2

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	Articles by authors
	LI Zhi-peng1
	YANG Fang1
	HU Zheng2
	ZHANG Qi-rui1
	QUAN Wei1
	XU Qiang1
	ZHANG Zhi-qiang1
	LU Guang-ming1

Cite this article:

LI Zhi-peng1,YANG Fang1,HU Zheng2, et al. Effect of levetiracetam in benign childhood epilepsy with centro-temporal spikes: #br# a resting-state fMRI study based on amplitude of low frequence fluctuation[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(10): 707-711.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I10/707

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