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| Validity and repeatability of CMR GRE for evaluating the heart function of rhesus monkey |
| ZHU Tong1, GONG Li2, CHEN Yu-shu1, ZHANG Yu1, LIANG Zhi-gang2, SUN Jia-yu1, #br#
CHENG Wei1, WANG Lei1, WU Bing1, ZHENG Jie3, ZENG Wen2, GAO Fa-bao1 |
1. Department of Radiology, West China Hospital, Sichuan University, Chengdu 610000, China;
2. Sichuan Primed Biotech Group Co., LTD, Chengdu 610000, China;
3. Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, MO, 63101, USA |
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Abstract Objective: To evaluate the validity and repeatability of GRE cine sequence when it was used to evaluate the heart function of rhesus monkey, and to provide an accurate and optimal cardiac function assessment strategy for the study of rhesus monkey cardiac disease models. Methods: Eight healthy rhesus monkeys underwent conventional echocardiography and CMR GRE cine sequence scanning to assess cardiac function and got left ventricular end-diastolic volume(EDV), left ventricular end-systolic volume(ESV), stroke volume(SV), ejection fraction(EF), cardiac output(CO), left ventricular end-diastolic mass (Myo Mass(Diast)) and left ventricular end-systolic mass(Myo Mass(Syst)). The repeatability of GRE was evaluated by the test-retest analysis. The validity of the GRE was evaluated by criterion-related validity by comparing the results of ultrasound and GRE. Results: The results of test-retest analysis showed that correlation coefficient(ICC) values of all function parameters were within 0.75～0.97, the P value was less than 0.01, and the results of repeated evaluation were better. The results of criterion-related validity showed that except for CO, the Pearson correlation coefficient(r) values of the other function parameters were 0.80～0.92, and the difference was statistically significant. It was found that EF, CO and Myo Mass(Diast) acquired by GRE were smaller than those measured by ultrasound, and the difference was statistically significant. Conclusion: There are good validity and repeatability using the CMR GRE cine sequence to evaluate the cardiac function of normal rhesus monkey.
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Received: 11 July 2017
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