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| The role of ADC value in the characterization of malignant breast tissues and
correlation between molecular subtypes of breast cancer |
| AYIKELIMU Muhamaitihan1, DENG Jia-min1, WANG Yun-ling1, MA Jing-xu1, JIA Wen-xiao2 |
| 1. Department of Radiology, the Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830063, China;
2. Xinjiang Medical University, Urumqi 830011, China |
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Abstract Objective: To investigate the role of apparent diffusion coefficient(ADC) value in the diagnosis of breast cancer and its association with tumor volume and hormonal receptors(estrogen receptor(ER), progesterone receptor(PR), and human epidermal growth factor(HER2)). Materials and Methods: Fifty-three patients with pathology-proven breast cancer and 31 with benign pathology were detected by diffusion weighted imaging(DWI) on 1.5T MR. ADC value and tumor size were measured respectively. Results: Mean ADC of malignant lesions was significantly lower((1.02±0.13)×10-3 mm2/s) compared to benign ((1.56±0.29)×10-3 mm2/s) lesions. A cutoff ADC value of 1.23×10-3 mm2/s(sensitivity 88.5%, specificity 85.1%, area under the curve 0.91) was obtained to differentiate malignant from benign diseases. Breast cancers with ER+, PR+, and triple-negative (TN) status showed a significantly larger tumor volume compared to ER+, PR+, and non-triple-negative (nTN) cancers, respectively. Furthermore, TN tumors showed a significantly higher ADC compared to ER+, PR+, and nTN cancers. Conclusion: ADC may increase the diagnostic specificity of DCE-MRI and be useful for evaluating prognosis of the tumor and guiding clinical therapy.
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Received: 09 January 2017
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| Cite this article: |
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AYIKELIMU Muhamaitihan1,DENG Jia-min1,WANG Yun-ling1, et al. The role of ADC value in the characterization of malignant breast tissues and
correlation between molecular subtypes of breast cancer[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(11): 785-788.
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| URL: |
| http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I11/785 |
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