基于CT征象区别肺浸润前病变与浸润性病变的可行性临床研究

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Abstract Objective: To analyze the CT features in differentiating pre-invasive and invasive lesion appearing as ground-glass nodule(GGN) retrospectively and obtain signs of discrimination. Methods: A total of 122 cases of GGNs were confirmed by pathology, 57 cases were pure GGNs and 65 cases were part solid GGNs. Seventy-one cases of invasive lesions, including 13 cases of atypical adenomatous hyperplasia(AAH) and 58 cases of adenocarcinoma in situ(AIS); invasive lesion in 51 cases, including 39 cases of minimally invasive adenocarcinoma(MIA) and 12 cases of invasive adenocarcinoma(IAC), we analyzed the difference between two groups of CT characteristics, ROC curve was used to identify the two groups of the best cut-off values. Results: In pure GGNs, size and lobulation were significant(P<0.05) and the cut-off of average diameterwas 11.82 mm, sensitivity and specificity were 73% and 87%. In part solid GGN, average diameter, solid proportion grade, lobulation, speculation and pleural retraction were statistically significant(P<0.05) and the cut-off value for average diameter in invasive lesion was 12.5 mm, sensitivity and specificity were 75% and 80%. Conclusion: The CT features could be used to pre-assess pre-invasive and invasive lesion appearing as GGN, the important factors are mainly reflected in the average diameter of GGN lesions, solid components and edge signs.

Key words： Lung neoplasms Tomography, spiral computed

Received: 10 April 2017

PACS:	Ｒ734.2
	Ｒ814.42

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	Articles by authors
	WU Guang-yao
	WANG Ke-xin
	SU La
	WU Jian-lin

Cite this article:

WU Guang-yao,WANG Ke-xin,SU La, et al. Feasibility of differentiating pre-invasive and invasive lesion appearing as ground-glass nodule based on CT features: a clinical study[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(12): 851-854.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2017/V28/I12/851

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