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| Study of real-time three-dimensional echocardiography in the assessment of left ventricular systolicsynchronization in patients with hypertrophic cardiomyopathy |
| CHEN Jun-hong1, LI Dong-ye2, WANG Zhi-rong1, XU Tong-da1, ZHANG Yan-bin1 |
| 1. Department of Cardiology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou Jiangsu 221000, China;2. Institute of Cardiovascular Disease, Xuzhou Medical College, Xuzhou Jiangsu 221000, China |
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Abstract Objective: To assess left ventricular myocardial systolic dyssynchrony in patients with hypertrophic cardiomyopathy(HCM) by real-time three-dimensional echocardiography(RT3DE). Methods: Forty patients with HCM, 25 age and sex matched normal controls underwent examinations with 2D and full volume RT3DE. Ejection fraction was >0.55 in all subjects. According to with or without left ventricular outflow tract obstruction at rest, HCM patients were divided into 2 groups, non-obstructive HCM group and obstructive HCM group. With QLab 7.0 off-line software the 17 segmental volume-time curves were obtained. The difference(Dif) and standard deviation(SD) of the time to the point with minimal systolic volume(Tmsv) in 16, 12, and 6 segments were measured and adjusted by R-R interval(Tmsv Dif%, Tmsv SD%). Results: Compared with control group, the Tmsv 16-SD%, and there were no significant differences between non-obstructive and obstructive HCM group. The left ventricle volume-time curves of the HCM patients had disordered arrangement compared with the normal control. Conclusion: Systolic asynchrony is impaired in HCM patients with or without left ventricular outflow tract obstruction. The RT3DE is an useful method for detecting left ventricular dyssynchrony of HCM patients and provide additional value for understanding myocardial damage of HCM patients.
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Received: 28 January 2014
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Corresponding Authors:
LI Dong-ye
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2014, Vol. 25 
