儿童小脑萎缩的影像学诊断路径：111例患者回顾分析

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Abstract Objective: To propose a neuroradiological diagnostic approach for childhood-onset cerebellar atrophy. Method: MR images of 111 patients with cerebellar atrophy were analyzed(62 males, 49 females). Hierarchical clustering of patients on the basis of their MRI item profile was performed. Result: Diagnosis was established in 76 patients. Mitochondrial diseases were the most common, followed by NCL and INAD. Hierarchical clustering result showed Cluster 1 mainly contained mitochondrial diseases, Cluster 2 mainly included INAD and NCL, Cluster 3 mainly included wilson disease, Cluster 4 mainly included Cockayne syndrome and Cluster 5 mainly includied ALD, MLD and Menks disease. Other diseases were comprised in Cluster 6. Conclusion: The diagnostic approach to childhood-onset cerebellar atrophy requires integration of neuroimaging results with clinical information. The use of neuroimaging pattern recognition is extremely useful in differential diagnoses and in the selection of further investigations.

Key words： Cerebellar diseases Atrophy Child Magnetic resonance imaging

Received: 05 June 2017

PACS:	Ｒ742.82
	Ｒ445.2

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	ZHAO Fei1
	XIAO Jiang-xi2
	XIE Sheng3

Cite this article:

ZHAO Fei1,XIAO Jiang-xi2,XIE Sheng3. Diagnostic approach to childhood-onset cerebellar atrophy: retrospective study of 111 patients[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(6): 381-386.

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http://www.jccmi.com.cn/EN/ OR http://www.jccmi.com.cn/EN/Y2018/V29/I6/381

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