Abstract Objective: To investigate the feasibility of dual-source dual-energy CT quantitative evaluation of Crohn’s disease activity. Methods: Thirty-eight patients with Crohn’s disease(CD) diagnosed by clinical manifestations, endoscopy, radiology and histopathology underwent CT enterography dual-energy double-phase contrast-enhanced radiography. According to the colonoscopy localization of Montreal, the bowel activity of the lesion was divided into three groups according to the Simple Endoscopic Score for Crohn’s Disease(SES-CD): mild activity, moderate activity and severe activity period. The differences of CT value, iodine value, normalized CT value and normalized iodine concentration(NIC) in intestine between different phases of arterial phase and portal venous phase were compared. According to the receiver operating characteristic(ROC) curve Diagnostic efficiency. Results: There were 53 lesions in 38 cases, including 7 segments of mild, 26 of moderate and 20 of severe. There were significant differences among the four parameters in the stages of intestine arterial phase and portal venous phase in different severity of disease and normal group(P<0.05), and increased with the increase of the severity. Except for the arterial phase CT value, the double-phase diagnosis of severe CD parameters are better performance, and portal phase were better than the arterial phase, portal phase NIC diagnostic efficacy of the highest threshold 0.59 mg/mL, sensitivity, specificity respectively, 80%, 84.8%, AUC=0.858. Conclusion: Quantitative parameters of dual-energy CT have great clinical value in assessing the severity of CD wall in CD patients, which can provide a basis for clinical diagnosis of CD activity.
WANG Chun-long,HAN Dan,HUANG Yi-long, et al. Feasibility study of dual-source CT dual-energy quantitative parameters evaluation of colon Crohn's disease activity[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(9): 640-644.
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2018, Vol. 29 
