头颈部非霍奇金淋巴瘤扩散加权成像ADC值与Ki-67表达相关性分析

doi:10.12117/jccmi.2020.01.002

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Abstract Objective: To investigate the correlation between apparent diffusion coefficient(ADC) and prognostic factor Ki-67 expression in non-Hodgkin’s lymphoma(NHL) of head and neck and the effect of ADC value in evaluating the efficacy of NHL chemotherapy. Methods: A total of 42 patients underwent MRI examination at our hospital and confirmed by pathology as NHL of head and neck from September 2016 to July 2018. They were divided into NK-T cell lymphoma(NKTCL) group and diffuse large B cell lymphoma(DLBCL) group, Ki-67 low expression group and Ki-67 high expression group, the changing group and the no changing group. The ADC value of each group was calculated and the correlation between the ADC value and the expression of Ki-67 was analyzed. Results: The average ADC value was negatively correlated with the Ki-67 index(r=-0.779, P=0.000). The average ADC value of low expression group was significantly higher than that of high expression group(P=0.000). The ADC values of Ki-67 low expression group and high expression group were negatively correlated with Ki-67 index(P＜0.05). The ADC values of DLBCL group and NKTCL group were negatively correlated with Ki-67 index(P＜0.05). The difference of the ADC value before and after chemotherapy in the changing group was significantly different(P＜0.05). The difference of ADC value of the changing group was significantly different with the no changing group(P＜0.05). Conclusion: The ADC value is related to the expression of Ki-67 in NHL of head and neck. The lower the ADC value is, the higher the Ki-67 index is in NHL. The changes of ADC value can monitor the effect of chemotherapy. Accordingly, DWI combined with MR routine scan can non-invasively evaluate the biological behavior in NHL of head and neck.

Key words： Lymphoma, non-Hodgkin Head and neck neoplasms Magnetic resonance imaging

Received: 01 February 2019

PACS:	Ｒ733.4
	Ｒ739.91
	Ｒ445.2

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	Articles by authors
	LIANG Yu-shuang
	XU Hui
	GUAN Ya-nan

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LIANG Yu-shuang,XU Hui,GUAN Ya-nan. Analysis of the correlation between ADC value of diffusion weighted imaging and #br# Ki-67 expression in non-Hodgkin lymphoma of head and neck[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(1): 6-10.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.01.002 OR http://www.jccmi.com.cn/EN/Y2020/V31/I1/6

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