IVIM在乳腺癌新辅助化疗后早期反应评估的应用价值

doi:10.12117/jccmi.2019.02.007

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Abstract Objective: To investigate the monitoring ability of early response to neoadjuvant chemotherapy in breast cancer based on intravoxel incoherent motion(IVIM). Methods: A retrospective analysis was performed on 30 cases of female patients with breast cancer neoadjuvant chemotherapy, who underwent IVIM examination of multiple b-value dual exponential signal attenuation model. Fifteen b-values were used, including 0, 25, 50, 75, 100, 150, 200, 500, 700, 800, 900, 950, 1 000, 1 200, 1 400 s/mm2 respectively. We divided all cases into pre-chemotherapy group and post-chemotherapy group. And pathologic diagnosis as golden standard, divided post-chemotherapy group into valid group and invalid group. Results: Compared with pre-chemotherapy, ADCslow value increased and f value decreased significantly in post-chemotherapy group(P=0.001; P=0.021). After two cycles of chemotherapy ADCslow was higher in the valid group and f value was lower in the invalid group(P=0.000; P=0.000). ADCfast showed no statistical significance(P=0.408). The prediction performance of ADCslow was higher than f value with AUC of 88.9%. The AUC of f value and ADCfast were 74.3% and 64.9% respectively. After comparing the difference before and after chemotherapy, ΔADCslow and Δf value were statistically significant(P<0.05) with AUC of 92.4% and 88.9% respectively. ΔADCfast showed no statistical significance(P=0.211) and the AUC is 70.8%. Conclusion: IVIM has value in evaluating the efficacy of breast cancer chemotherapy. ADCslow and f value have such potential ability while ΔADCslow value most.

Key words： Breast neoplasms Antineoplastic combined chemotherapy protocols Magnetic resonance imaging

Received: 05 March 2018

PACS:	Ｒ737.9
	Ｒ445.2

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	Articles by authors
	XIONG Fa-kui1
	CUI Feng1
	GONG Liang-geng2

Cite this article:

XIONG Fa-kui1,CUI Feng1,GONG Liang-geng2. The application value of IVIM in the assessment of early reaction after neoadjuvant chemotherapy for breast cancer[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(2): 102-105.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2019.02.007 OR http://www.jccmi.com.cn/EN/Y2019/V30/I2/102

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