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| Myocardial fibrosis detected by late gadolinium enhancement in dilated cardiomyopathy and the relationship between left ventricular function and plasma NT-proBNP levels |
| ZHANG Ying-xue1, ZHAO Xin-xiang2 |
1. Department of Radiology, Nanyang Central Hospital, Nanyang Henan 473000, China;
2. Department of Radiology, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China |
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Abstract Objective: To investigate the relationship between myocardial fibrosis detected by late gadolinium enhancement(LGE) and the left ventricular function as well as plasma NT-proBNP levels in dilated cardiomyopathy(DCM). Methods: Twenty-two cases of DCM were enrolled. All patients were examined by CMR and had NT-proBNP detection. According to the results of LGE, all cases were divided into group A(without LGE) and group B(with LGE). Group B were further divided into two subgroups, including group Ba(the number of LGE segments＜5) and group Bb(the number of LGE segments≥5). The LVEDV, LVESV, LVEF, SV, CO, CI, LVMM, FS, LVEDD SI and plasma NT-proBNP levels were analyzed and compared among groups. Result: There were sixteen(73%) cases with myocardial fibrosis detected by LGE. The most frequent locations were basal anteroseptal(13 cases) and basal inferoseptal segments (13 cases). The second most frequent locations were mid-anteroseptal(7 cases) and mid-inferoseptal segments(7 cases). Eight cases showed mutiple segments of myocardial fibrosis. The significant differences of LVEDV, LVESV, LVEF, LVMM, FS, LVEDD SI and plasma NT-proBNP levels were seen between group A and group B(P＜0.05), and the group B had poorer cardiac function and ventricular remodeling. Compared group Ba and group Bb, the significant differences of LVEDV, LVESV, LVEF, LVMM, FS, LVEDD SI and plasma NT-proBNP levels were seen(P＜0.05), and the group Bb showed worse ventricular remodeling and higher NT-proBNP levels. Conclusion: The presence and extent of myocardial fibrosis detected by LGE can reflect the severity of cardiac structure and function after ventricular remodeling in patients with DCM. The more numbers of myocardial fibrosis segments in patient with DCM are found, the poorer cardiac function, the worse ventricular remodeling and the higher the plasma NT-proBNP level will happen.
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Received: 22 October 2018
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