术前NLR联合AFP对肝细胞癌患者TACE术后预后的预测价值

doi:10.12117/jccmi.2019.10.008

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Abstract Objective: To investigate the predictive value of preoperative neutrophil to lymphocyte ratio(NLR) in peripheral blood combined serum alpha-fetoprotein(AFP) on prognosis in patients with hepatocellular carcinoma(HCC) who received TACE. Methods: Two hundred and thirty five HCC patients were divided into four groups according to the preoperative peripheral blood NLR level and serum AFP level. The association of NLR combined with AFP level and clinicopathological features was analyzed. The overall survival rate(OS) and disease free survival rate(DFS) of these four groups were also compared. Results: The level of preoperative NLR combined with AFP was significantly associated with several clinicopathological characteristics, including maximum diameter of tumor, BCLC stage, and HBsAg level. Among the four groups, HCC patients with low NLR and low AFP exhibited the highest OS and DFS, whereas those with high NLR and high AFP showed the lowest OS and DFS. Both univariate and multivariate Cox regression analysis indicated that preoperative NLR combined with AFP level was an independent risk factor for worse prognosis. Conclusion: Preoperative NLR in peripheral blood combined with serum AFP can be a reliable indicator for prognosis in HCC patients who underwent TACE, and HCC patients with high level of preoperative NLR and serum AFP have a poor survival rate.

Key words： Carcinoma, hepatocellular alpha-Fetoproteins Radiology, interventional

Received: 08 October 2018

PACS:	Ｒ735.7
	Ｒ815

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	Articles by authors
	LIU Hua-jiang
	DENG Tang
	YAN Yun-zhi
	JIN Gui-yun

Cite this article:

LIU Hua-jiang,DENG Tang,YAN Yun-zhi, et al. Predictive value of preoperative neutrophil to lymphocyte ratio combined with alpha-fetoprotein on prognosis in patients with hepatocellular carcinoma after TACE[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(10): 716-720.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2019.10.008 OR http://www.jccmi.com.cn/EN/Y2019/V30/I10/716

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