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| Application value of MSCT perfusion imaging in the pre-surgical diagnosis of renal cell carcinoma |
| MO Lei, WANG Hai-lin, GU Jie-hong, FU Jun-zhou |
| Department of Radiology, the First People Hospital of Guangzhou, Guangzhou 510180, China |
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Abstract Objective: To evaluate the value of multiple spiral CT(MSCT) perfusion imaging in the pre-surgical diagnosis, staging, assessing the renal blood flow and the tumor angiogenesis of renal cell carcinoma(RCC). Methods: The study included 38 cases of RCC, 18 cases of renal pelvic carcinoma(RPC) and 8 cases of renal angiomyolipoma(RAML) proved by surgery and pathology. Target-slice dynamic perfusion scanning was performed in all patients before surgery. Regions of interest(ROI) were drawn within the tumor, the region of normal area adjacent to the tumor and the other side. Relevant parameters including blood flow(BF), blood volume(BV), mean transit time(MTT）, permeability surface(PS） and time-density curve(TDC) were analyzed using perfusion software. Result: ①There were significant association for BF, BV and PE between different tumor cell grades, RCC and normal renal cortex.②Of the 38 RCC, especially the grade II and III, the mean BF, BV, PS and peak enhancement(PE） value were higher than that of RPC. ③The time of peak(PT） of RCC were obviously earlier than that of normal renal cortex, RPC and RAML. There were significant differences between them. ④The MTT value of grade II and III RCC were obviously lower than that of normal renal cortex. There were no significant differences of MTT between RCC, RPC and RAML. ⑤Perfusion of RCC was much higher than that of RPC and RAML. Conclusion: There are distinctive characteristics of MSCT perfusion imaging in RCC, which help to assess the renal blood flow and the tumor angiogenesis and provides useful information for pre-surgical diagnosis and staging of RCC. MSCT perfusion imaging is a promising technique for clinical evaluation and prediction of prognosis in RCC.
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Received: 27 March 2007
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2007, Vol. 18 
