Abstract Objective: To investigate the value of CT in the diagnosis of gastrointestinal stromal tumor(GIST). Methods: 14 cases with GISTs which have been proved by postsurgical pathology were retrospectively analyzed. Results: 7 of the 13 GISTs were benign, 4 were potentially malignant, 2 was malignant, 1 was not sure to be benign or malignant. 1 of the 14 GISTs was from the esophagus, 8 were from the stomach, 3 were from the jejunum and ileum, 2 were from the colon. The tumors diameter were range 1 to 15cm. The tumors were round, oval or irregular in shape. 11 of the 14 GISTs were exophytic, 2 were endophytic, 1 was exo- and endophytic. 13 GISTs were cystic-solid with inhomogenous attenuation. The solid potion of masses enhanced moderately to markedly after the contrast media administrated. Conclusion: CT is the main tool for preoperational diagnosis and definition of GIST’s biological behavior.