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| Abnormal functional connectivity of the insula in type 2 diabetes mellitus: a resting-state functional MRI study |
| WANG Man1, ZHANG Dong-sheng2, QI Fei1, SU Yu1, XIE Qing-ming1, TANG Min2, ZHANG Xiao-ling2 |
| 1. Xi’an Medical College, Xi’an 710000, China;
2. Department of MRI, Shaanxi Province People’s Hospital， Xi’an 710068, China |
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Abstract Objective: To investigate whether type 2 diabetes mellitus(T2DM) causes abnormal functional connectivity between the insula and the whole brain and its role in the neural mechanism of T2DM brain injury. Methods: A total of 33 patients with T2DM and healthy subjects(HC) matched with demographic data were included. All subjects underwent resting-state fMRI and neuropsychological tests to observe the difference in functional connectivity between the insula and the whole brain between the two groups, and the mean value of functional connections of significantly different brain regions were extracted. Then the correlation between the extracted mean value of functional connections and clinical data and neuropsychological evaluation was analyzed. Results: Compared with HC, the insula showed decreased functional connectivity between bilateral inferior frontal gyrus, right superior temporal gyrus, left angular gyrus and left cerebellum in T2DM patients, and no brain areas with enhanced functional connections were found. Moreover, the functional connectivity between the insula and the right inferior frontal gyrus in T2DM patients was negatively correlated with HbA1c(r=-0.379, P=0.035). Conclusion: There is a wide range of functional connectivity abnormalities between the insula and whole brains of T2DM patients, which may be the neurological basis of auditory and visual spatial function impairment. Continuous high glucose status may cause IC function impairment in T2DM patients.
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