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| PCNA, MVD expression in prostate cancer and CDFI flow detection |
| DONG Chang-yuan, WANG Ling, WANG Xian-ming, YI Jian-hua, YAO Qi-sheng |
| Affiliated Taihe Hospital of Yunyang Medical College, Shiyan Hubei 442000, China |
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Abstract Objective: To assess the relationship between the proliferation cell nuclear antigen(PCNA), microvascular density(MVD) expression and CDFI flow detection with clinical pathology in prostate cancer. Method: In 27 cases prostate cancer and 29 cases hyperplasia, the flow signal were detected by Color Dopper flow imaging(CDFI), and the grading of artery flow in the prostate and the resistance index(RI) was recorded, and then the MVD and PCNA expression in the relevant sample was detected by immune histochemistry technique(SP). Results: The PCNA, MVD expression in cancer group was well correlated to flow grading and the pathological differentiation, and in the high grade tumor and poor differentiation ones, the MVD, PCNA expression tend to increase. RI, PCNA, MVD in metastatic cases were stronger than those in non-metastatic cases. In prostate hyperplasia group, PCNA, MVD expression and flow grading and RI were more lower than those in the cancer group, which have significant difference between the two groups（P＜0.05）. Conclusions: The blood flow detection by CDFI and the MVD, PCNA expression can effectively reflect angiogenesis in prostate cancer, will help to clinical therapy planning and predict prognosis.
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Received: 09 April 2006
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2007, Vol. 18 
