Correlation of color Doppler ultrasound in breast cancer and cell protein expression
1. Shaanxi University of Chinese Medicine, Xianyang Shaanxi 712046, China; 2. Department of Ultrasound,
the Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang Shaanxi 712083, China
Abstract：Objective: To explore the correlation between color Doppler ultrasound findings and the expression levels of ER, PR, CerbB-2, Ki-67 and P53 in breast cancer and the clinical significance. Methods: Ninety-seven patients of breast cancer confirmed pathologically were examined by color Doppler ultrasound and the expression levels of ER, PR, CerbB-2, Ki-67 and P53 was analyzed and correlated with the ultrasound findings. Results: In the 97 cases of breast cancer, the positive rates of ER, PR, CerbB-2, Ki-67, and P53 were 68.04%, 61.86%, 77.32%, 60.82% and 56.70%, respectively. ①In the group of small masses, the positive expression rates of ER and PR were higher than those in their corresponding group, but the CerbB-2 was opposite, with statistically significant differences(P<0.05). ②In the group with uniform internal echo, the positive expression rates of PR and P53 were higher than those in the corresponding group, with statistically significant differences(P<0.05). ③In the group with spiculation, the positive expression rates of ER, PR, CerbB-2, Ki-67, P53 were higher than those in the corresponding group, and the differences were statistically significant(P<0.05).④In microcalcification group, the positive expression rates of ER, PR, CerbB-2, Ki-67, P53 were higher than those in no microcalcification group, with statistically significant differences(P<0.05). ⑤In the group with rich blood supply, the positive expression rates of ER, PR, CerbB-2, Ki-67 were higher than those in the group lack of blood supply, with statistically significant differences(P<0.05). ⑥In the group with positive lymph nodes, the positive expression rates of ER, PR CerbB-2, P53 were higher than those in the corresponding group, with statistically significant differences(P<0.05). Conclusion: Ultrasound findings are closely related to the pathology of breast cancer. Ultrasonic morphological characteristics of cancer might predict the expression of some types of proteins. The level of the proteins and the ultrasound features, including spiculation, microcalcification, blood supply and lymph node metastasis, are effective indicators of the malignancy grade. Combination of the ultrasound features and molecular biomarkers can play a crucial role in early evaluating of treatment and prognosis of breast cancer.
赵 妮1，姚秀芬1，赵素萍2. 乳腺癌彩色多普勒超声与细胞蛋白表达的相关性研究[J]. 中国临床医学影像杂志, 2016, 27(7): 462-466.
ZHAO Ni1, YAO Xiu-fen1, ZHAO Su-ping2. Correlation of color Doppler ultrasound in breast cancer and cell protein expression. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(7): 462-466.
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