Preliminary clinical study in side effect and diagnostic value of adenosine 201Tl myocardial perfusion imaging for detecting coronary artery disease
CHEN Gui-bing1, JIANG Ning-yi2, LIU Sheng2, LU Xian-ping2, LIANG Jiu-gen2, ZHANG Hong2, WU Hua1
1.Department of Nuclear Medicine, the First Hospital, Fujian Medical University, Xiamen Fujian 361003, China;2.Department of Nuclear Medicine, the Second Affiliated Hospital of Zhongshan University, Guangzhou 510120, China
Abstract：Objective: The aims of this study were to evaluate the side effect and diagnostic value of adenosine 201Tl myocardial perfusion imaging for detecting coronary artery disease(CAD). Methods: A total of 21 patients with suspected CAD were submitted with adenosine stress myocardial perfusion imaging. Adenosine was injected by minipump(140 microgram per kg body weight per minute). The total time of adenosine infusion was 6 minutes. At the third minute of adenosine infusion, a bolus of 1.295×108Bq thallium-201 was injected, and SPECT acquisition of burden imaging was obtained at 2 minutes after completion of adenosine infusion. After 2~4 hours redistribution imaging was obtained. Coronary angiography (CAG) was performed in all patients within 2 weeks. Results: In adenosine stress myocardial perfusion imaging, the sensitivity, specificity, positive predictive value, negative predictive value, accuracy were 92.86%, 57.14%, 81.25%, 80.0%, 80.95% respectively. The positive diagnostic rate of single, two and three branches lesions were 83.33%, 100% and 100% respectively. Total positive diagnostic rate was 92.86%. Conclusion: Domestic adenosine stress myocardial perfusion imaging is a safe and reliable diagnostic method for CAD. It has mild side effects, high sensitivity and accuracy in CAD diagnosis.
2006, Vol. 17 
