1.Department of Nuclear Medicine, the Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China;2.State Key Laboratory of Medical Biology Technology, Nanjing University, Nanjing 210093, China
Abstract：Objective: To investigate the biodistribution of 99Tcm-H-Annexin V in normal mice and rabbit. Methods: H-Annexin V was labeled directly with 99Tcm. The labeling rate was determined and the specific activity was calculated. The biodistrbution of 99Tcm-H-Annexin V was studied at 1, 10, 30, 60, 120 and 240min after injection in normal mice. The scintigraphy of 99Tcm-H-Annexin V was performed in normal rabbit for 240min, combining the region of interest(ROI) time-activity curve analysis. Results: The radiolabeling rate and specific activity of 99Tcm-H-Annexin V were(96.80±0.35)％ and (12.30±0.06)TBq/mmol respectively. Biodistribution in mice showed rapid blood and renal clearance with gradually excreted in other organs or tissues including heart, liver, lungs, and muscle. Low uptake at brain was also observed throughout the whole course of the studies. In rabbit, rapid uptake and clearance in the genito-urinary system with gradually decreased uptake with time in other organs or tissues was observed. Conclusion: 99Tcm-H-Annexin V is an easily prepared and labeled compound with high labeling efficiency and stability.
贾支俊;冯雪凤;杨 翔;华子春;申景涛;郭万华. 99Tcm-H-Annexin V动物体内分布及显像[J]. , 2008, 19(1): 56-58.
JIA Zhi-jun;FENG Xue-feng;YANG Xiang;HUA Zi-chun;SHEN Jing-tao;GUO Wan-hua. Study on biodistribution and imaging of 99Tcm-H-Annexin V in normal animals. , 2008, 19(1): 56-58.
2008, Vol. 19 
