Abstract：Distant metastasis is common in advanced colorectal cancer(CRC). The most common site of metastases is the liver. According to incomplete statistics, more than half patients with CRC will have liver metastases before or after surgery. For such patients, treatment is usually limited and their survival life is usually short. This is a main reason for the poor prognosis of colorectal cancer. As a new treatment method, radiofrequency ablation(RFA) can inactivate the tumor locally in situ by ablation, which has become an important means of comprehensive treatment of patients with colorectal cancer liver metastases(CRLM). With the expansion of medical indications, more and more CRLM patients choose radiofrequency ablation. The article reviewed current clinical applications of RFA therapy in CRLM, aiming to provide evidence for CRLM through RFA.
张国宁，刘兆玉. 射频消融在结直肠癌肝转移中的临床应用进展[J]. 中国临床医学影像杂志, 2016, 27(1): 59-61.
ZHANG Guo-ning, LIU Zhao-yu. The clinical application of radiofrequency ablation in colorectal cancer liver metastases. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(1): 59-61.
[1]Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014[J]. Ca Cancer J Clin, 2014, 64(2): 104-117.
[2]Ma Y, Yang Y, Wang F, et al. Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies[J]. Plos One, 2013, 8(1): 350-352.
[3]Solbiati L, Ahmed M, Cova L, et al. Small liver colorectal metastases treated with percutaneous radiofrequency ablation: local response rate and long-term survival with up to 10-year follow-up[J]. Radiology, 2013, 265(3): 958-968.
[4]Minami Y, Kudo M. Radiofrequency ablation of liver metastases from colorectal cancer: a literature review[J]. Gut Liver, 2013, 7(1): 1-6.
[5]Kwan BY, Kielar AZ, Elmaraghi RH, et al. Retrospective Review of Efficacy of Radiofrequency Ablation for Treatment of Colorectal Cancer Liver Metastases From a Canadian Perspective[J]. Ca Assoc Radiol J, 2014, 65(1): 77-85.
[6]殷文胜，张锡鹏，华杨，等. 大肠癌合并肝转移术中行射频消融术41例分析[J]. 中国误诊学杂志，2011，11（4）：954.
[7]姚宏伟，王良，修典荣. 微创技术在结直肠癌肝转移诊断及治疗中的应用[J]. 中华普通外科杂志，2012，27（11）：957-959.
[8]Abitabile P, Hartl U, Lange J, et al. Radiofrequency ablation permits an effective treatment for colorectal liver metastasis[J]. Eur J Surg Oncol, 2007, 33(1): 67-71.
[9]Jasarovic D, Stojanovic D, Mitrovic N, et al. Resection or radiofrequency ablation of colorectal liver metastasis[J]. Vojnosanitetski pregled. Military-medical and pharmaceutical review, 2014, 71(6): 542-546.
[10]潘文倩，徐军，尹益民，等. 结肠直肠癌肝转移的射频消融治疗[J]. 现代肿瘤医学，2014，22（12）：2934-2935.
[11]Kawaguchi Y, Hasegawa K, Saiura A, et al. Surgical resection for local recurrence after radiofrequency ablation for colorectal liver metastasis is more extensive than primary resection[J]. Scand J Gastroenterol, 2014, 49(5): 569-575.
[12]Crissien AM, Frenette C. Current Management of Hepatocellular Carcinoma[J]. Gastroenterol Hepatol, 2014, 10(3): 153-161.
[13]Ke S, Ding XM, Qian XJ, et al. Radiofrequency ablation of hepatocellular carcinoma sized >3 and ≤ 5 cm: Is ablative margin of more than 1 cm justified?[J]. World J Gastroenterol, 2013, 19(42): 7389-7398.
[14]杨枫，刘展，李云涛，等. 腹腔镜结直肠癌切除术联合射频消融治疗肝转移癌[J]. 中华消化外科杂志，2009，8（1）：27-29.
[15]陈丽羽. 射频消融在结直肠癌肝转移治疗中的应用现状[J]. 当代医学，2013，19（17）：11-13.
[16]赵明，王健鹏，吴沛宏. 射频消融治疗结直肠癌肝转移的现状[J]. 中华肿瘤杂志，2011，33（6）：401-404.
[17]Mayo SC, Heckman JE, Shore AD, et al. Shifting trends in liver-directed management of patients with colorectal liver metastasis: a population-based analysis[J]. Surgery, 2011, 150(2): 204-216.
[18]Ruers T, Punt C, Van CF, et al. Radiofrequency ablation combined with systemic treatment versus systemic treatment alone in patients with non-resectable colorectal liver metastases: a randomized EORTC Intergroup phase Ⅱ study(EORTC 40004)[J]. Ann Oncol, 2012, 23(9): 2619-2626.
[19]Jin Y, Cai Y, Cao Y, et al. Radiofrequency ablation combined with systemic chemotherapy in nasopharyngeal carcinoma liver metastases improves response to treatment and survival outcomes[J]. J Surg Oncol, 2012, 106(3): 322-326.
[20]Stoltz A, Gagnière J, Dupré A, et al. Radiofrequency ablation for colorectal liver metastases[J]. J Visceral Surg, 2014, 151(suppl 1(2)): S33-S44.
[21]Cucchetti A, Piscaglia F, Cescon M, et al. Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma[J]. J Hepatol, 2013, 59(2): 300-307.
[22]Weng M, Zhang Y, Zhou D, et al. Radiofrequency Ablation versus Resection for Colorectal Cancer Liver Metastases: A Meta-Analysis[J]. Plos One, 2012, 7(9): 1472-1472.
[23]高君，孙文兵. 射频消融在结直肠癌肝转移综合治疗中的地位[J]. 中国医刊，2014，49（12）：8-10.
2016, Vol. 27 
