乳腺癌彩色多普勒超声与细胞蛋白表达的相关性研究

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摘要目的：探讨乳腺癌彩色多普勒超声征象与其细胞蛋白表达指标ER、PR、CerbB-2、Ki-67、P53的相关性及临床意义。方法：经手术病理证实的97例乳腺癌患者进行彩色多普勒超声检查，并对照其细胞蛋白ER、PR、CerbB-2、Ki-67、P53的表达水平，分析两者相关性。结果：97例乳腺癌标本中各细胞蛋白阳性表达率分别为ER（68.04%）、PR（61.86%）、CerbB-2（77.32%）、Ki-67（60.82%）、P53（56.70%）；①在小肿块组中ER、PR阳性表达率高于其对应组阳性表达率，CerbB-2阳性表达率则相反，差异均有统计学意义（P<0.05）。②在内部回声不均匀组中PR、P53阳性表达率高于对应组，差异有统计学意义（P<0.05）。③在毛刺组中ER、PR、CerbB-2、Ki-67、P53阳性表达率均比对应组高，且差异有统计学意义（P<0.05）。④在微小钙化组中CerbB-2、Ki-67、P53的阳性表达率高于无微钙化组，差异有统计学差异（P<0.05）。⑤在富血供组的ER、PR、CerbB-2、Ki-67阳性表达率均高于乏血供组，差异有统计学意义（P<0.05）。⑥在淋巴结转移阳性组的ER、 PR、CerbB-2、P53阳性表达率高于对应组，差异有统计学意义（P<0.05）。结论：乳腺癌超声声像图表现与病理组织学变化密切相关，肿块的超声形态特点对细胞蛋白表达有提示作用，其中病灶的毛刺征、微钙化、富血供及淋巴结转移征象与其对应的细胞蛋白是恶性度的强预测指标，联合应用超声征象与分子生物学指标对评估乳腺癌早期治疗及预后有重要临床价值。

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	赵妮1
	姚秀芬1
	赵素萍2

关键词 ：乳腺肿瘤；超声检查, 多普勒, 彩色

Abstract：Objective: To explore the correlation between color Doppler ultrasound findings and the expression levels of ER, PR, CerbB-2, Ki-67 and P53 in breast cancer and the clinical significance. Methods: Ninety-seven patients of breast cancer confirmed pathologically were examined by color Doppler ultrasound and the expression levels of ER, PR, CerbB-2, Ki-67 and P53 was analyzed and correlated with the ultrasound findings. Results: In the 97 cases of breast cancer, the positive rates of ER, PR, CerbB-2, Ki-67, and P53 were 68.04%, 61.86%, 77.32%, 60.82% and 56.70%, respectively. ①In the group of small masses, the positive expression rates of ER and PR were higher than those in their corresponding group, but the CerbB-2 was opposite, with statistically significant differences(P<0.05). ②In the group with uniform internal echo, the positive expression rates of PR and P53 were higher than those in the corresponding group, with statistically significant differences(P<0.05). ③In the group with spiculation, the positive expression rates of ER, PR, CerbB-2, Ki-67, P53 were higher than those in the corresponding group, and the differences were statistically significant(P<0.05).④In microcalcification group, the positive expression rates of ER, PR, CerbB-2, Ki-67, P53 were higher than those in no microcalcification group, with statistically significant differences(P<0.05). ⑤In the group with rich blood supply, the positive expression rates of ER, PR, CerbB-2, Ki-67 were higher than those in the group lack of blood supply, with statistically significant differences(P<0.05). ⑥In the group with positive lymph nodes, the positive expression rates of ER, PR CerbB-2, P53 were higher than those in the corresponding group, with statistically significant differences(P<0.05). Conclusion: Ultrasound findings are closely related to the pathology of breast cancer. Ultrasonic morphological characteristics of cancer might predict the expression of some types of proteins. The level of the proteins and the ultrasound features, including spiculation, microcalcification, blood supply and lymph node metastasis, are effective indicators of the malignancy grade. Combination of the ultrasound features and molecular biomarkers can play a crucial role in early evaluating of treatment and prognosis of breast cancer.

Key words： Breast neoplasms Ultrasonography, Doppler, color

收稿日期: 2015-11-30

PACS:	Ｒ737.9
	Ｒ445.1

通讯作者: 姚秀芬

作者简介: 赵妮（1989-），女，陕西榆林人，在读硕士研究生。E-mail：215970931@qq.com

引用本文:

赵妮1，姚秀芬1，赵素萍2. 乳腺癌彩色多普勒超声与细胞蛋白表达的相关性研究[J]. 中国临床医学影像杂志, 2016, 27(7): 462-466.
ZHAO Ni1, YAO Xiu-fen1, ZHAO Su-ping2. Correlation of color Doppler ultrasound in breast cancer and cell protein expression. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(7): 462-466.

链接本文:

http://www.jccmi.com.cn/CN/ 或 http://www.jccmi.com.cn/CN/Y2016/V27/I7/462

[1]苟凌云，刘健. 早期乳腺癌的影像学诊断进展[J]. 中华临床医师杂志：电子版，2013，14（14）：167-169.
[2]徐兵河. 乳腺癌的分子靶向治疗进展[J]. 中国医科大学学报，2013，42（12）：1057-1064.
[3]Adler DD, Carson PL, Rubin JM, et al. Doppler ultrasound color flow imaging in the study of breast cancer: preliminary finding[J]. Ultrasound Med Biol, 1990, 16(6): 553-559.
[4]林韵，王小燕. 乳腺癌超声征象与分子生物学指标相关性的研究进展[J]. 医学综述，2014，20（5)：800-803.
[5]Nishimura RI, Osako T, Okumura Y, et al. Changes in the ER, PgR, HER2, p53 and Ki-67 biological markers between primary and recurrent breast cancer: discordance rates and prognosis[J]. World J Surg Oncol, 2011, 9(20): 1944-1950.
[6]Schnitt SJ. Molecular biology of breast tumor progression: a view from the other side[J]. Int J Surg Pathol, 2010, 18(3 Suppl): 170S-173S.
[7]Duchnowska RI, Jassem J, Goswami CP, et al. Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients[J]. Neurooncol, 2015, 122(1): 205-216.
[8]Li FY, Wu SG, Zhou J, et al. Prognostic value of Ki-67 in breast cancer patients with positive axillary lymph nodes: a retrospective cohort study[J]. PLoS One, 2014, 9(2): e87264.
[9]Yamashita H, Toyama T, Nishio M, et al. p53 protein accumulation predicts resistance to endocrine therapy and decreased post-relapse survival in metastatic breast cancer[J]. Breast Cancer Res, 2006, 8(4): R48.
[10]李秀昆，梁桂欣，刘磊，等. 乳腺癌彩色多普勒超声特征及病理分型研究[J]. 中国实验诊断学，2012，16（1）：109-111.
[11]Ghosh J, Gupta S, Desai S, et al. Estrogen, progesterone and her2 receptor expression in breast tumors of patients, and their usage of her2-targeted therapy, in a tertiary care centre in India[J]. Indian J Cancer, 2011, 48(4): 391-396.
[12]Azizun N, Bhurgri Y, Raza F, et al. Comparison of ER, PR and HER-2/neu(CerbB-2) reactivity pattern with histologic grade, tumor size and lymph node status in breast cancer[J]. Asian Pac J Cancer Prev, 2008, 9(4): 553-556.
[13]Yerushalmi R, Woods R, Ravdin PM, et al. Ki67 in breast cancer: prognostic and predictive potential[J]. Lancet Oncol, 2010, 11(2): 174-183.
[14]Qi F. Correlation of CerbB-2 to Ki-67 and P53 expressions in hormone-independent breast cancer[J]. J Southern Med Univ, 2011, 31(2): 380-382.
[15]Cools-Lartigue J, Sinclair A, Trabulsi N, et al. Preoperative axillary ultrasound and fine-needle aspiration biopsy in the diagnosis of axillary metastases in patients with breast cancer: predictors of accuracy and future implications[J]. Ann Surg Oncol, 2013, 20(3): 819-827.
[16]Sharifah NAI, Lee BR, Clarence-Ko CH, et al. C-erbB-2 onco-protein expression in breast cancer: relationship to tumor characteristics and short-term survival in Universiti Kebansaan Malaysia Medical Centre[J]. Asian Pac J Cancer Prev, 2008, 9(4): 663-670.
[17]李辉，孙俊杰. 乳腺癌的影像学诊断现状与进展[J]. 中华全科医学，2014，12（3）：448-451.