Functional MRI study of the functional language area with brain tumor preoperatively related with the semantic and syntactic paradigm
1. Foshan Hospital of Traditional Chinese Medicine, Foshan Guangdong 528000, China;
2. Guangdong General Hospital, Guangdong Academy of Medical Sciences Guangzhou 510080, China;
3. The First People’s Hospital of Foshan, Foshan Guangdong 528000, China
Abstract：Objective: To observe the location and the language lateralization of language functional areas in patients with brain tumors. To evaluate the relationship between the location of the lesion and the language lateralization of functional language areas, and determine the Chinese language hemisphere. Finally analyzed the cause of this phenomenon. Methods: Nineteen patients were enrolled the study, to perform the semantic and syntactic paradigm. Functional data was collected when performed the language tasks and analyzed by SPM8. Using specify 2nd level(single sample t-test) for group analysis. Then locating the functional language areas and determining the Chinese language hemisphere. Results: In the case of 19 patients with brain tumors, bilateral medial frontal gyrus, bilateral superior frontal gyrus, right medial frontal gyrus, bilateral superior temporal gyrus, left inferior temporal gyrus, left middle temporal gyrus, the bilateral supramarginal gyrus etc were significantly activated. The LI was more than 0. The dominant hemisphere in patients with brain tumor was in left side. Conclusion: The mass effect due to growth of the brain tumors led to the restructuring of the brain tissue. And the normal brain regions around the lesion and the right hemisphere corresponding mirror brain areas may compensate for the part of the language function. BOLD-fMRI provides a reliable method for evaluating the relationship between the location of the lesion and the functional language areas. It is helpful for perfectly excision of the lesion in the surgery.
刘泳坚1，黄 飚2，周守国1，冯燕韻3，梁长虹2，张家雄1. 脑肿瘤患者术前语义、语法任务相关的脑语言功能磁共振成像研究[J]. 中国临床医学影像杂志, 2016, 27(8): 533-537.
LIU Yong-jian1, HUANG Biao2, ZHOU Shou-guo1, FENG Yan-yun3, LIANG Chang-hong2, ZHANG Jia-xiong1. Functional MRI study of the functional language area with brain tumor preoperatively related with the semantic and syntactic paradigm. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(8): 533-537.
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