健康成人脑白质扩散峰度成像与年龄相关性变化的初步研究

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摘要目的：应用扩散峰度成像（DKI）探讨健康成人脑白质组织微观结构与年龄的相关性变化。方法：对60例正常志愿者进行常规MRI和DKI扫描，志愿者按年龄分为3组：青年组（20～＜40岁）20例、中年组（40～＜60岁）20例、老年组（≥60岁）20例，经后处理得到DKI相关参数图。于外囊、内囊前肢和后肢、胼胝体膝部和压部、半卵圆中心、额叶选取感兴趣区测定相关参数值，包括各向异性分数（FA）、平均峰度（MK）、径向峰度（RK）、轴向峰度（AK）值，并作统计学分析。结果：内囊前肢、胼胝体膝部、压部、半卵圆中心、额叶FA值与年龄呈显著负相关（P＜0.05），其中，内囊前肢、额叶FA值表现为：青年组＞老年组（P＜0.017），胼胝体膝部、压部、半卵圆中心FA值表现为：青年组＞中年组，青年组＞老年组。各选取白质感兴趣区MK值与年龄呈显著负相关，其中，外囊、内囊后肢、胼胝体膝部、压部、半卵圆中心、额叶MK值表现为：青年组＞中年组＞老年组，内囊前肢MK值表现为：青年组＞中年组，青年组＞老年组。各选取白质感兴趣区RK值与年龄呈显著负相关。其中，内囊前肢、胼胝体膝部、压部、半卵圆中心、额叶RK值表现为：青年组＞中年组＞老年组，外囊、内囊后肢RK值表现为：青年组＞中年组，青年组＞老年组。AK值与年龄无显著相关。脑白质FA平均值、MK平均值、RK平均值与年龄呈显著负相关（r值分别为-0.775、-0.933、-0.946），脑白质AK平均值与年龄无显著相关。结论：较传统DTI，DKI能更全面、更敏感地探测健康成人脑白质组织微观结构与年龄的相关性变化。

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	谢铭飞
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关键词 ：脑；年龄因素；磁共振成像, 弥散

Abstract：Objective: To explore age-related changes of healthy adult white matter microstructure with diffusion kurtosis imaging(DKI). Methods: Sixty volunteers were divided into three groups according to age: 20 cases of young group(20～＜40 years), 20 cases of middle-aged group(40～＜60 years), 20 cases of elder group(≥60 years). Conventional MRI and DKI were performed. Fractional anisotropy(FA), mean kurtosis(MK), radial kurtosis(RK) and axial kurtosis(AK) were determined in the external capsule, the anterior limb of the internal capsule(ALIC), the posterior limb of the internal capsule(PLIC), the genu of the corpus callosum(CC), the splenium of the CC, the centrum semiovale, the frontal subcortical white matter(sWM). Parameter estimates were obtained and statistically analysed. Results: FA values in the ALIC, genu and splenium of the CC, centrum semiovale and frontal sWM were significant negative correlation with age(P<0.05). FA values in the ALIC and frontal sWM were shown as follows: young group>elder group(P<0.017). FA values in the genu and splenium of the CC and centrum semiovale were shown as follows: young group>middle-aged group, young group>elder group. MK values in the all selected white matter areas were significant negative correlation with age. MK values in the external capsule, PLIC, genu and splenium of the CC, centrum semiovale and frontal sWM were shown as follows: young group>middle-aged group>elder group. MK values in the ALIC were shown as follows: young group>middle-aged group, young group>elder group. RK values in the all selected white matter areas were significant negative correlation with age. RK values in the ALIC, genu and splenium of the CC, centrum semiovale and frontal sWM were shown as follows: young group>middle-aged group>elder group. RK values in the external capsule and PLIC were shown as follows: young group>middle-aged group, young group>elder group. AK values in the all selected white matter areas did not show age dependence. The average FA, MK and RK values from all selected white matter areas were significant negative correlation with age(r values were -0.775, -0.933 and -0.946, respectively). The average AK values did not show age dependence. Conclusion: DKI can offer a more comprehensive and sensitive detection of age-related changes of healthy adult white matter microstructure compared with DTI.

Key words： Brain Age factors Diffusion magnetic resonance imaging

收稿日期: 2016-01-18

PACS:
	Ｒ338.25
	Ｒ445.2

通讯作者: 高思佳，中国医科大学附属第一医院放射科，110001。E-mail：scarlettgao@126.com

作者简介: 谢铭飞（1989-），男，江西萍乡人。医师。现工作单位为华中科技大学同济医学院附属协和医院放射科。E-mail：xmfly1989@163.com

引用本文:

谢铭飞，高思佳，胡文，苏宇，李丹. 健康成人脑白质扩散峰度成像与年龄相关性变化的初步研究[J]. 中国临床医学影像杂志, 2016, 27(10): 685-689.
XIE Ming-fei, GAO Si-jia, HU Wen, SU Yu, LI Dan. A preliminary study of age-related changes of healthy adult white matter with diffusion kurtosis imaging. JOURNAL OF CHINA MEDICAL IMAGING, 2016, 27(10): 685-689.

链接本文:

http://www.jccmi.com.cn/CN/ 或 http://www.jccmi.com.cn/CN/Y2016/V27/I10/685

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