Abstract：Objective: To investigate the feasibility, clinical efficacy and influencing factors of 125I particles in the treatment of malignant tumors. Methods: The clinical data of 38 patients with malignant tumors treated by CT-guided 125I seed therapy in our hospital from April 2013 to March 2016 were retrospectively analyzed. The preoperative and postoperative tumor volume changes of 2 months and 6 months were compared. According to the changes of tumor volume, blood supply or tumor metabolic changes, the curative effect was graded(CR: complete remission, PR: partial remission, SD: tumor stability, PD: progression of disease, CR+PR for the total effective rate), and its short-term curative effect was evaluated. The data were analyzed by SPSS 17.0 statistical software before and after operation. The t test was used for statistical analysis. The difference of P<0.05 was statistically significant. Results: Postoperative 2 months, CR: 3 cases, PR: 18 cases, SD: 15 cases, PD: 2 cases, CR+PR: 55.26%; 6 months after operation, CR: 6 cases, PR: 21 cases, SD: 9 cases, PD: 2 cases; CR+PR: 71.05%. There was a significant difference in tumor volume at preoperative and postoperative 2 and 6 months(P<0.05). Conclusion: 125I seed implantation is a safe and effective method for the treatment of malignant tumor with less trauma, less adverse reaction, and satisfactory clinical efficacy in the control of tumor growth and the clinical symptoms of patients.
陈中乾，田 丰，何广顺，赵晓朋，周东海. CT引导下125I粒子植入治疗恶性肿瘤的临床研究[J]. 中国临床医学影像杂志, 2017, 28(4): 282-284.
CHEN Zhong-qian, TIAN Feng, HE Guang-shun, ZHAO Xiao-peng, ZHOU Dong-hai. Clinical research of CT-guided 125I seed implantation in the treatment of malignant tumor. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(4): 282-284.
[1]张云峰，曹贵文，宁厚法，等. 125I放射性粒子植入治疗腹膜后淋巴结转移的临床研究[J]. 医学影像学杂志，2013，23（9）：1430-1433.
[2]王俊杰，黄毅，马力文． 放射性粒子种植治疗前列腺癌[M]． 北京：北京医科大学出版社，2002：47-73．
[3]林俊清，杨维竹，江娜，等. CT引导下125I放射性粒子植入治疗原发性肝细胞癌伴门静脉癌栓[J]. 中国介入影像与治疗学，2011，8（4）：299-302.
[4]李鸿汀，谢旺容，黄蓉，等． CT引导下125I放射性粒子治疗肝癌源性肺转移癌[J]． 医学影像学杂志，2014，24（3）：392-394.
[5]Zhang J, Zhang JG, Song TL, et al. 125I seed implant brachytherapy-assistant surgery with preservation of facial nerve for the treatment of parotid gland malignant tumor[J]. Int J Oral Maxillofac Surg, 2008, 37(6): 515-520.
[6]Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1 765 cases with long-term follow-up[J]. Am J Surg Pathol, 2005, 29(1): 52-68.
[7]王旭东，曹贵文，宁厚法，等． TACE围手术期静脉用三氧化二砷联合125I粒子治疗原发性肝癌的近期疗效研究[J]． 医学影像学杂志，2013，23（5）：799-802．
[8]程义壮，姚晓波，张然，等． 晚期恶性肿瘤的放射性粒子植入治疗的临床研究[J]. 安徽医学，2012，33（8）：978-979.
[9]刘胜中，曾富春，冯刚，等. 术中植入125I放射性粒子在非小细胞肺癌治疗中的应用[J]. 四川医学，2011，32（3）：340-342.
[10]霍小东，郑广钧，柴树德，等. CT引导下125I粒子植入治疗Ⅲ期非小细胞肺癌疗效分析[J]. 中华放射医学与防护杂志，2012，32（2）：199-203.
[11]刘士榕，肖越勇，吴斌，等. CT引导下125I放射性粒子组织间植入治疗纵隔转移性淋巴结[J]. 中华放射学杂志，2011，45（12）：1190-1193.
