Abstract：Objective: To evaluate the diagnostic value of MR perfusion weighted imaging(PWI) for liver fibrosis in rabbit model. Methods: MR PWI was performed in the experimental group(n=40) and the control group(n=10). Time to peak(TP), wash-in rate and wash-out rate were compared with histological results by using one-way ANOVA Least significant difference(LSD) was used between two groups. The diagnostic efficiency of staging liver fibrosis was done by using ROC curve analysis. Results: With the deterioration of liver fibrosis, time to peak(TP) of liver parenchyma increased gradually, however, the wash-in rate and wash-out rate decreased. For TP, there was signifcant difference among stage S0~S2, S3 and S4(P<0.05). For wash-in rate, there was signifcant difference among stage S0 and S2, S3 and S4(P<0.05). Concerning wash-out rate, S3 and S4 stage can be distinguished from S0~S2 stage(P<0.05). After merging fibrosis stages, there was signifcant difference among stage S0 and ≥S1, ≤S1 and ≥S2, ≤S2 and ≥S3, ≤S3 and S4(P<0.05). Conclusion: Combining the TP and the signal rise maximum slope rate can reflect perfusion changes of liver fibrosis in different periods with highest diagnostic efficiency in stages over S2.
韩秉艳，王 皓，王云玲，王禄伟，王 红，贾文霄. MR灌注加权成像评价兔肝纤维化分期的实验研究[J]. 中国临床医学影像杂志, 2017, 28(7): 484-487.
HAN Bing-yan, WANG Hao, WANG Yun-ling, WANG Lu-wei, WANG Hong, JIA Wen-xiao. The values of MR perfusion weighted imaging in evaluating rabbit liver fibrosis. JOURNAL OF CHINA MEDICAL IMAGING, 2017, 28(7): 484-487.
[1]Wynn TA. Integrating mechanisms of pulmonary fibrosis[J]. Ex Med, 2011, 20(8): 339-350.
[2]张弘，陶森，郝彧，等. 国外肝纤维化诊断的研究热点分析[J]. 首都医科大学学报，2016，37（1）：83-88.
[3]罗爽，邢卉春． 肝纤维化无创诊断的相关研究进展[J]． 中国肝脏病杂志，2014，6（3）：87-90．
[4]Ellis EL, Mann DA． Clinical evidence for the regression of liver fibrosis[J]． J Hepatol, 2012, 56(5): 1171-1180.
[5]De Robertis R, D’onofrio M, Noninvasive E, et al． Diagnosis of cirrhosis: arevie of different imaging modalities[J]. World J Gastroenterol, 2014, 20(23): 7231-7241.
[6]Elpek Go. Angiogenesis and liver fibrosis[J]． World J Hepatol, 2015, 7(3): 377-391.
[7]Lee SJ, Kim KH, Park KK. Mechanisms of fibrogenesis in liver cirrhosis: the molecular aspects of epithelial-mesenchymal transition[J]. World, 2014, 6(4): 207-216.
[8]梁明帮，黎进莲，安玉松，等. CT肝灌注成像在肝纤维化诊断中的价值及影像特点分析[J]． 中西医结合肝病杂志，2015，25（5）：295-297.
[9]肖国明. CT灌注成像在诊断肝纤维化、肝硬化中的应用[J]． 中国医药科学，2015，13（2）：169-170.
[10]刘鑫，郭启勇，廖伟，等. 肝纤维化磁共振灌注成像的初步实验研究[J]. 中国临床医学影像杂志，2009，20（6）：442-445.
[11]孟令平，王国光，胡明秀，等. 大鼠肝纤维化和肝硬化MR-PWI参数与CD34和ａ-SMA的相关性[J]. 放射学实践，2016，31（7）：580-585.
[12]Kanematsu M, Goshima S, Watanab E, et al. Difusion/perfusion MR imagining of the liver: practice, challenges, and future[J]. Magn Reson Med Sci, 2012, 11(3): 151-161.
