Abstract：Objective: To investigate the differences and correlations of Ki67 expression and ADC value in mass-like and non-mass-like breast cancer. Methods: Ninety-one patients with non-specific type breast cancer in our hospital from September 2014 to December 2016 were analyzed retrospectively. All the subjects undertook MRI examination(plain scan, DWI and DCE-MRI) before operation or biopsy. Routine pathological examination and the expression of Ki67 were detected by immunohistochemical method on specimens. The differences of Ki67 expression and ADC value were compared between mass-like and non-mass-like breast cancer groups, and correlations between Ki67 expression and ADC value were analyzed in two groups respectively. Results: The expression of Ki67 was (32.42±14.943)% and (25.81±10.416)% in mass-like breast cancer group(60/91) and non-mass-like breast cancer group(31/91), and significant difference was observed between the two groups(t=2.200, P<0.05). ADC value was (0.575±0.215)×10-3 mm2/s and (1.14±0.718)×10-3 mm2/s in mass-like breast cancer group and non-mass-like breast cancer group with significant difference(t=-4.280, P<0.05). In non-mass-like breast cancer, the ADC value was lower in invasive cancer than DCIS(P<0.05). No relationship was found between the expression of Ki67 or ADC value in either group(P>0.05). Conclusion: Compared with non-mass-like breast cancer, mass-like breast cancer shows higher Ki67 expression level and lower ADC value. In non-mass-like breast cancer, invasive breast cancer has lower ADC value. No relationship was found between the expression of Ki67 or ADC value in either mass-like or non-mass-like breast cancer.
李 芹，牛庆亮，杜汉旺，郑召龙，朱亚宁. 肿块型与非肿块型乳腺癌ADC值、Ki67指数的对比分析[J]. 中国临床医学影像杂志, 2018, 29(1): 11-13.
LI Qin, NIU Qing-liang, DU Han-wang, ZHENG Zhao-long, ZHU Ya-ning. Comparative analysis of ADC value and Ki67 index in mass-like and non-mass-like breast cancer. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(1): 11-13.
[1]高才良，乐暾，蔡福玲，等. 动态增强MRI及扩散加权成像对乳腺癌的诊断价值研究进展[J]. 磁共振成像，2016，7（3）：235-240.
[2]Kanemaki Y, Kurihara Y, Okamoto K, et al. Ductal carcinoma in situ: correlations between high-resolution magnetic resonance imaging and histopathology[J]. Radiat Med, 2007, 25(1): 1-7.
[3]Kontzoglou K, Palla V, Karaolanis G, et al. Correlation between Ki67 and breast cancer prognosis[J]. Oncology, 2013, 84: 219-225.
[4]Sun JZ, Chen C, Jiang G, et al. Quantum dot-based immunofluorescent imaging of Ki67 and identification of prognostic value in HER2-positive(non-luminal) breast cancer[J]. Int J Nanomedicine, 2014, 9: 1339-1346.
[5]Molinari C, Clauser P, Girometti R, et al. MR mammography using diffusion weighted imaging in evaluating breast cancer: a correlation with proliferation index[J]. Radiol Med, 2015, 120(10): 911-918.
[6]Costantini M, Beli P, Rinaldi P, et al. Diffusion-weighted imaging in breast cancer: relationship between apparent diffusion coefficient and tumor aggressiveness[J]. Clin Radiol, 2010, 65(12): 1005-1012.
[7]Partridge SC, Mullins CD, Kurland BF, et al. Apparent diffusion coefficient values for discriminating benign and malignant breast MRI lesions: effects of lesion type and size[J]. AJR, 2010, 194(6): 1664-1673.
[8]Karaman A, Durur-Subasi I, Alper F, et al. Correlation of diffusion MRI with the Ki67 index in non-small cell lung cancer[J]. Radiol Oncol, 2015, 49(3): 250-255.
[9]Choi SY, Chang YW, Park HJ, et al. Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer[J]. Br J Radiol, 2012, 85(1016): e474-479.
[10]Martincich L, Deantoni V, Bertotto I, et al. Correlation between diffusion-weighted imaging and breast cancer biomarkers[J]. Eur Radiol, 2012, 22(7): 1519-1528.
2018, Vol. 29 
