Abstract：Objective: To compare the value of renal dynamic imaging and contrast-enhanced ultrasound in assessment of early renal damage in patients with hypertension． Methods: Forty cases of hypertension were included in our study, and 30 healthy volunteers were enrolled as normal control group. Each patient had normal results in blood serum urea nitrogen(BUN)and serum creatinine(SCr) tests. Hypertension patients and control group were randomly divided into C group(with CEUS) and S group(with SPECT), and the renal function were quantitatively analyzed. Results: In CEUS group, compared with normal control, the curves of hypertension patients were more blunt, and the ascending and descending rates were slower. The AUC and TTP were increased, PI was decreased(P<0.05), and the MTT was increased(P>0.05). In SPECT group, GFR of hypertension patients showed a downward trend compared with normal control group without statistically significant difference(P>0.05). Conclusion: Compared with SPECT, CEUS is more sensitive in assessment of early renal damage in patients with hypertension, and can provide easy, safe and sensitive monitoring indexes for early renal damage.
张国慧，梁 蕾，郭 君. 超声造影与SPECT肾动态显像在原发性高血压早期肾损伤中的对比研究[J]. 中国临床医学影像杂志, 2018, 29(1): 34-37.
ZHANG Guo-hui, LIANG Lei, GUO Jun. Comparison of renal dynamic imaging and contrast-enhanced ultrasound in assessing early renal damage in patients with hypertension. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(1): 34-37.
[1]Collins AJ, Foley RN, Chavers B, et al. United States Renal Data System 2011 Annual Data Report: Atlas of chronic kidney disease & end-stage renal disease in the United States[J]. Am J Kidney Dis, 2012; 59(1 Suppl 1): A7, e1-420.
[2]钟方明，高艳香，郑金刚. 高血压肾损害发病机制的研究进展[J]. 中日友好医院学报，2015，29（6）：364-366.
[3]任建平. 血清胱抑素C在原发性高血压早期肾损伤中的检测意义[J]. 中国实验诊断学，2014，18（2）：275-276.
[4]付燕，赵斌. 急性肾损伤早期诊断的生物标志物[J]. 中华危重病急救医学，2012，24（9）：571-573.
[5]Piscaglia F, Nolsoe C, Dietrich CF, et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound(CEUS): update 2011 on non-hepatic applications[J]. Ultraschall in der Medizin, 2012, 33（1）: 33-59.
[6]Wilson SR, Burns PN. Microbubble-enhanced US in body imaging: what role?[J]. Radiology, 2010, 257（1）: 24-39.
[7]Kitzman DW, Goldman ME, Gillam LD, et al. Efficacy and safety of the novel ultrasound contrast agent perflutren(definity) in patients with suboptimal baseline left ventricular echocardiographic images[J]. Am J Cardiol, 2000, 86（6）: 669-674.
[8]Piscaglia F, Bolondi L, Italian Society for Ultrasound in M, Biology Study Group on Ultrasound Contrast A. The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations[J]. Ultrasound Med Biol, 2006, 32（9）: 1369-1375.
[9]Granata A, Floccari F, Logias F, et al. [Contrast enhanced ultrasound in renal diseases]. Giornale italiano di nefrologia: organo ufficiale della Societa italiana di nefrologia, 2012, 29(Suppl 57): S25-35.
[10]McArthur C, Baxter GM. Current and potential renal applications of contrast-enhanced ultrasound[J]. Clin Radiol, 2012, 67(9): 909-922.
[11]Nilsson A. Contrast-enhanced ultrasound of the kidneys[J]. Eur Radiol, 2004, 14(Suppl 8): P104-109.
[12]李建华，冯蕾，孙琰，等. 超声造影评估慢性肾动能不全患者肾血流灌注的研究[J]. 中国医学影像学杂志，2012，20（7）：520-523.
[13]Setola SV, Catalano O, Sandomenico F, et al. Contrast-enhanced sonography of the kidney[J]. Abdom Imaging, 2007, 32(1): 21-28.
[14]Ma F, Cang Y, Zhao B, et al. Contrast-enhanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage[J]. Nephrol Dialysis Transpl, 2012, 27(7): 2891-2898.
[15]Siracusano S, Bertolotto M, Ciciliato S, et al. The current role of contrast-enhanced ultrasound(CEUS) imaging in the evaluation of renal pathology[J]. World J Urol, 2011, 29(5): 633-638.
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