Abstract：Objective: To investigate the Tau protein expression and glutamate(Glu) characteristics in basal ganglia following hypoxic-ischemic(HI) reperfusion brain injury in a piglet model, further defined the Tau protein and Glu in the role of HI brain injury mechanism. Methods: A total of 45 healthy piglets(3~5 days old, 1.0~1.5 kg) were divided into control(n=9) and hypoxic-ischemic(HI) model groups(n=36). The HI model group was further divided into six groups according to 1H-magnetic resonance spectroscopy(1H-MRS) scan times after HI(0~2 h, 2~6 h, 6~12 h, 12~24 h, 24~48 h and 48~72 h). Measure Tau protein and Glu at different time points after HI in basal ganglia and the correlation of Tau protein and Glu, P<0.05 considered statistically significant, the decimal to 2 digits. Results: The results of 1H-MRS showed that after HI, the Tau protein content increased first, then decreased, and reached the highest point in 24~48 h, which was statistically different from the control group. Glu appears to rise first, then decreases, then rises again, showing a “bimodal” change, which peaks at 6~12 h and 24~48 h. Tau protein and Glu were positively correlated, correlation coefficient r=0.76(P<0.05). Conclusions: These results indicate that after HI, Tau protein and Glu work together on the neural networks and neurons and glial cells in the brain.
郑 阳，王晓明. 新生猪缺氧缺血性脑损伤后基底节区Tau蛋白与谷氨酸变化的相关研究[J]. 中国临床医学影像杂志, 2018, 29(8): 543-547.
ZHENG Yang, WANG Xiao-ming. Study of relationship between Tau protein changes and glutamate expression in basal ganglia after hypoxic-ischemic reperfusion injury in piglets. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(8): 543-547.
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