伴抑郁症状的精神分裂症患者的功能连接强度变化研究

doi:DOI:10.12117/jccmi.2018.08.006

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摘要目的：探究伴抑郁症状的精神分裂症患者功能连接强度（FCS）改变，分析精神分裂症患者的抑郁症状和全脑FCS的相关性。方法：本研究共纳入91例精神分裂症患者及89名健康对照者，所有的受试者均进行了静息态下功能磁共振成像检查。通过阳性和阴性症状量表中的一般精神病理量表第6项对91例患者进行抑郁症状的评价，评分大于1分的患者被认为伴有抑郁症状，反之则认为无抑郁症状。运用多重回归分析的方法探究精神分裂症患者中FCS的变化和抑郁症状严重程度的相关性。然后，根据患者是否伴有抑郁症状，采用单因素方差分析比较与抑郁症状相关脑区的FCS值在无抑郁症状组、伴抑郁症状组和健康对照组之间的差异。结果：精神分裂症患者的双侧颞上回FCS改变与其抑郁症状有关，并且伴抑郁症状组的双侧颞上回FCS显著高于无抑郁症状组和对照组。结论：双侧颞上回异常FCS增强可能是精神分裂症患者出现抑郁症状的神经机制。

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	郭力宁1
	禚传君2
	秦文1
	于春水1

关键词 ：精神分裂症, 抑郁症, 磁共振成像

Abstract：Objective: To investigate functional connectivity strength(FCS) changes underlying depressive symptoms in patients with schizophrenia(SZ) and to analyze correlation depressive symptoms with FCS. Methods: Ninety-one SZ patients and 89 healthy controls(HC) were recruited to undergo a resting-state functional magnetic resonance imaging. The positive and negative symptom scale(PANSS) general psychopathology scale item 6(G6) was used to assess the severity of depressive symptoms in SZ. Patients were defined as depressed with scores of PANSS-G6>1, otherwise they were categorized into the non-depressed group(NDSZ). The correlation between FCS and depression severity was tested using multiple regression analysis in SZ. The FCS maps correlated with the depression symptoms were compared with one-way ANOVA among the three groups. Results: Depressive scores were strongly correlated with FCS values in the bilateral superior temporal gyrus(STG) in SZ patients. The FCS values in the bilateral STG were significantly increased in DSZ compared to NDSZ and HC. Conclusion: Schizophrenia patients with depressive symptoms have stronger FCS in the bilateral STG, which may be a possible neural mechanism of the depressive symptoms in these patients.

Key words： Schizophrenia Depressive disorder Magnetic resonance imaging

收稿日期: 2018-05-22

PACS:	Ｒ749.3
	Ｒ749.41
	Ｒ445.2

基金资助:国家自然科学基金（编号81425013）；慢性病防治科技重大专项（17ZXMFSY00090）；天津市重点研发计划科技支撑重点项目（编号14ZCZDSY00018）。

通讯作者: 于春水，天津医科大学总医院医学影像科，300052。E-mail：chunshuiyu@tijmu.edu.cn

作者简介: 郭力宁（1991-），男，河北晋州人，在读硕士研究生。E-mail：18334721302@163.com

引用本文:

郭力宁1，禚传君2，秦文1，于春水1. 伴抑郁症状的精神分裂症患者的功能连接强度变化研究[J]. 中国临床医学影像杂志, 2018, 29(8): 552-555.
GUO Li-ning1, ZHUO Chuan-jun2, QIN Wen1, YU Chun-shui1. A study of altered resting-state functional connectivity strength in depressed schizophrenia. JOURNAL OF CHINA MEDICAL IMAGING, 2018, 29(8): 552-555.

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http://www.jccmi.com.cn/CN/DOI:10.12117/jccmi.2018.08.006 或 http://www.jccmi.com.cn/CN/Y2018/V29/I8/552

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