基于CT双气相扫描对COPD患者肺容积定量研究

doi:10.12117/jccmi.2019.09.003

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摘要目的：基于数字肺测试平台对吸、呼双相CT肺容积定量分析，探讨CT肺容积定量测量在正常人与慢性阻塞性肺疾病（Chronic obstructive pulmonary disease，COPD）中的临床应用价值。方法：初步收集我院2016年11月—2018年2月，正常人91例和COPD患者61例的双气相胸部CT数据。采用128层螺旋CT进行双气相胸部扫描，所得图像导入数字肺测试平台进行分析，统计分析软件采用SPSS 20.0。结果：COPD双气相肺容积差异具有统计学意义，P＜0.01，且吸气相肺容积（LVin）＞呼气相肺容积（LVex）。COPD与正常人双气相肺容积差异具有统计学意义，P＜0.01，且正常人肺叶容积明显小于COPD患者。定量分析正常人与COPD患者各肺叶双气相肺容积结果显示：无论吸气相或呼气相肺容积差异均以左肺上叶变化最显著（吸气相肺容积差约（506.57±119.39）mL，呼气相差约（468.74±111.2）mL），变化最小的是右肺中叶（肺容积差约（115.45±36.07）mL）。结论：CT定量测量可判断各肺叶病变的严重程度，一方面对COPD患者有一定的临床诊断价值，同时呼气相可辅助吸气相评价COPD病变程度；另一方面，对肺减容手术的评估提供有效的临床价值。

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	王雷
	赵凡惠
	李建龙
	黄晓旗

关键词 ：肺疾病, 慢性阻塞性, 肺容量测定, 体层摄影术, 螺旋计算机

Abstract：Objective: To explore the clinical value of quantitative measurement of lung volume by CT in normal people and chronic obstructive pulmonary disease(COPD) based on quantitative analysis of lung volume by digital lung test platform. Methods: Dual-phase chest CT data of 91 cases of healthy people and 61 cases of COPD from November 2016 to February 2018 were collected. 128-slice spiral CT was used for dual-phase chest scan. The images were imported into the digital lung test platform for analysis. SPSS 20.0 was used for statistical analysis software. Results: The difference in double-phase lung volume of COPD was statistically significant(P＜0.01), and the inspiratory lung volume(LVin) >expiratory lung volume(LVex). The difference in double-phase lung volume between COPD group and normal group was statistically significant(P＜0.01), and the lung lobe volume of normal group was significantly smaller than that of COPD group. Quantitative analysis of dual-phase lung volume in each lung of normal group and COPD group: The difference of lung volume in both inspiratory or expiratory phases was most significant in the left upper lobe(the inspiratory lung volume difference was about (506.57±119.39) mL, the expiratory difference was about (468.74±111.2) mL), the difference of the right middle lobe was the smallest(the difference in lung volume was about (115.45±36.07) mL). Conclusion: CT quantitative measurement can determine the severity of each lung lesions. On the one hand, it has certain clinical diagnostic value for patients with COPD, and the expiratory phase can assist inspiratory phase to evaluate the severity of COPD lesions, on the other hand, it can provides effective clinical value for the evaluation of lung volume reduction surgery.

Key words： Pulmonary disease, chronic obstructive Lung volume measurements Tomography, spiral computed

收稿日期: 2018-09-05

PACS:	Ｒ563
	Ｒ814.42

基金资助:延安市科技攻关计划项目（2018KS-11）；延安市科技惠民计划（2017-HM-07-01）。

通讯作者: 黄晓旗，延安大学附属医院CT诊断科，716000。E-mail：344653354@qq.com

作者简介: 王雷（1991-），男，陕西人，在读硕士研究生。E-mail：805942896@qq.com

引用本文:

王雷，赵凡惠，李建龙，黄晓旗. 基于CT双气相扫描对COPD患者肺容积定量研究[J]. 中国临床医学影像杂志, 2019, 30(9): 617-620.
WANG Lei, ZHAO Fan-hui, LI Jian-long, HUANG Xiao-qi. Quantitative study of lung volume in patients with chronic obstructive pulmonary disease based on#br# CT dual-phase scanning. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(9): 617-620.

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http://www.jccmi.com.cn/CN/10.12117/jccmi.2019.09.003 或 http://www.jccmi.com.cn/CN/Y2019/V30/I9/617

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