Abstract：Objective: To investigate the diagnostic value of 3.0T MRI in HER-2 negative and HER-2 overexpression subtype of mass-like breast invasive ductal cancer. Methods: Retrospective analysis of 79 women in Wuxi No.2 People’s Hospital confirmed breast invasive ductal cancer masses histopathologically was performed between August 2016 and October 2017, aged from 25 years to 73 years, all the patients received 3.0T MR scan. Preoperative diffusion weighted imaging and dynamic contrast-enhanced MR were acquired, we measured and analyzed the MRI imaging and parameters of the masses and compared the statistics. Results: All of 79 patients with breast invasive ductal cancer masses were clearly shown by MR images. There were 45 patients with HER-2 negative and 34 patients with HER-2 overexpression. There were no statistically significant difference among age, the tumor size, the signal of DWI, ADC value and the time-intensity curve between HER-2 negative and overexpression groups in 3.0T MRI. Compared with the shape, margin, the way of enhancement and of the HER-2 negative and HER-2 overexpression breast cancer, the distinction has statistically significant. The masses in HER-2 negative group tended to show as round or oval, clear margin, ring and homogeneous enhancement. The masses in HER-2 overexpression group tended to show as irregular shape, irregular or spiculate margin and inhomogeneous enhancement. Conclusions: 3.0T MRI partial features(the shape, margin, the way of enhancement) were useful for the prediction and diagnosis of HER-2 negative and HER-2 overexpression breast cancer, and to select and formulate an optimal treatment plan for patients with different types of breast cancer．
姜春娟，王中娟，张追阳，祁秀敏. 3.0T MRI在HER-2阴性与HER-2过表达型肿块型乳腺浸润性导管癌中的应用[J]. 中国临床医学影像杂志, 2019, 30(8): 540-543.
JIANG Chun-juan, WANG Zhong-juan, ZHANG Zhui-yang, QI Xiu-min. The diagnostic value of 3.0T MRI in HER-2 negative and HER-2 overexpression subtype of mass-like breast invasive ductal cancer. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(8): 540-543.
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