Abstract Objective: The purpose of this study was to evaluate the right ventricular(RV) dyssynchrony in pulmonary hypertension(PH) patients using equilibrium radionuclide angiography(ERNA). Methods: Thirty-five PH patients and twenty healthy controls were included. ERNA was performed to calculate both RV ejection fraction(RVEF) and dyssynchrony parameters including RV phase shift(RVmPA) and RV phase standard deviation(RVPSD). The 6-minute walking distance(6-MWD) and N-terminal pronatriuretic peptide(NT-proBNP) were also detected to evaluate RV function of PH patients. Results: The mean RVEF, RVmPA and RVPSD of the PH group were 36.57±7.43%, (403.91±81.78)ms, and (54.46±15.05)ms, respectively. Compared with the control group, RVEF was significantly decreased(P<0.001), while RVmPA and RVPSD were significantly increased(P<0.001). RVmPA and RVPSD were significantly correlated with RVEF, 6-MWD and NT-proBNP(RVmPA: r=0.725, 0.645, 0.633, P<0.001; RVPSD: r=0.804, 0.733, 0.725, P<0.001). Conclusion: ERNA is feasible to evaluate RV mechanical dyssynchrony in PH patients. RV dyssynchrony parameters measured by phase analysis of ERNA were significantly correlated with RV function.
CHEN Yu,GU Yang,LIN Zhen-yu, et al. Assessment of right ventricular dyssynchrony in patients with pulmonary hypertension using equilibrium radionuclide angiography[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(1): 4-7.
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2019, Vol. 30 
