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| MRI findings on cognitive impairment and alteration of cerebral grey matter density in COPD patients |
| XU Wei-wei, LU Chun-qiang, JU Sheng-hong |
| The Medical School of Southeast University, Nanjing 210009, China |
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Abstract Objective: To investigate the type of cognitive impairment, the change of grey matter density and the relationship between grey matter density change and cognitive impairment in the stable chronic obstructive pulmonary disease(COPD) patients. Methods: Twenty-five stable COPD patients and 26 healthy controls were enrolled from June 2014 to June 2016. MRI examination and neuropsychologic tests were performed in all the subjects. The voxel-based morphometry(VBM) method was used to compare the grey matter density between the two groups. Results: Compared to healthy controls, the COPD patients had a lower score on the mini-mental state examination(MMSE), montreal cognitive assessment(MoCA), digit span, digit symbol test, trail making-A test, and trail making-B test. The VBM results showed that the grey matter density of the right supramarginal gyrus, inferior parietal lobule and right cerebellum were significantly lowered compared to that of the controls. The grey matter density of the right cerebellum was positively correlated with the score of MoCA and digit span backward test. Conclusion: The cognitive impairment of the stable COPD patients lies mainly on non-amnestic cognitive impairment and presents with the impairment of the executive control function. Many brain areas exhibits lowered grey matter density in stable COPD patients. The reduced grey matter density is associated with the cognitive impairment. MRI examination can provide useful information in diagnosis and evaluation of the cognitive impairment in COPD patients.
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Received: 18 January 2018
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