胎儿透明隔间腔异常的MRI产前诊断价值

doi:10.12117/jccmi.2019.07.007

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Abstract Objective: To analyze and discuss the prenatal MRI features and diagnostic value of the fetal cavum septum pellucidum and its associated neurological abnormalities. Methods: From June 2015 to June 2018, 2 361 cases of fetuses from Sichuan Provincial Women and Children Hospital were included in our research. All the fetuses received 1.5T MR and ultrasonography(US) examination. We gathered the clinical information and analyzed the MR imaging. Results: 332 fetuses detected by MRI examination of fetal head revealed cavum septum pellucidum and associated nervous system abnormalities. In these cases, ultrasonography indicated 212 cases of cavum septum pellucidum. The age of the maternal and gestational week was 17~41 years old and 21~39W+3, respectively. MRI presented 221 cases of fetuses with pure cavum septum pellucidum abnormality, including 8 of complete absence of cavum septum pellucidum, 7 cases of partial absence, 92 cases of broadening, and 114 cases of narrowing. One hundred and eleven cases of fetus with cavum septum pellucidum anomaly combined with other neurological abnormalities, including 68 cases of corpus callosum complete absence, 16 cases of corpus callosum partial absence, 3 cases of visual-septal dysplasia, 9 cases of holoprosencephaly（HPE, including 2 alobar HPE, 2 semilobular HPE and 5 lobar HPE), 3 cases of Schizencephaly, 4 cases of brain injury, 4 cases of hydrocephalus, 2 cases of multiple malformations and 2 cases of porencephaly. Conclusions: MRI findings and presentations of fetal cavum septum pellucidum and combined neurological abnormality were characteristic. MRI has obvious advantages over US, which can manifest fetus central nervous system abnormalities not detected by US. MRI can diagnose more accurately and improve the accuracy of prenatal diagnosis of fetal central nervous system abnormalities so that reduce the birth rate of children with major defects.

Key words： Septum pellucidum Fetal diseases Magnetic resonance imaging

Received: 13 February 2019

PACS:	Ｒ714.53
	Ｒ445.2

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	Articles by authors
	TAO Yuan-ping
	KANG Min
	CAO Qian
	CHEN Xia
	CHEN Rui
	WANG Qi-yan

Cite this article:

TAO Yuan-ping,KANG Min,CAO Qian, et al. The value of prenatal diagnosis for abnormality of fetal cavum septum pellucidum by MRI[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2019, 30(7): 487-494.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2019.07.007 OR http://www.jccmi.com.cn/EN/Y2019/V30/I7/487

[1]Winter TC, Kennedy AM, Byrne J, et al． The cavun septipellucidi: why is it important?[J]. Ultrasound Med, 2010, 29(3): 427-444. [2]刘彦英，陈青，李谊，等. 透明隔腔在胎儿颅脑超声检查中的临床意义[J]. 中国超声医学杂志，2010，26（9）：834-836. [3]姚志彬. 临床神经解剖学[M]. 广州：世界图书出版公司，2001：19. [4]刘炜，蔡爱露. 透明隔腔的超声诊断及其临床意义[J]. 中国临床医学影像杂志，2008，19（5）：353-355. [5]International Society of Ultrasound in Obstetrics and Gynecology Education Committee. Sonographic examination of the fetal central nervous system: guidelines for performing the “basic examination” and the “fetal neurosonogram”[J]. Ultrasound Obstet Gynecol, 2007, 29(1): 109-116. [6]Falco P, Gabrielli S, Visentin A, et al. Transabdominal sonography of the cavum septum pellucidum in normal fetuses in the second and third trimesters of pregnancy[J]. Ultrasound Obstet Gynecol, 2000, 16(6): 549-553. [7]Serhatlioglu S, Kocakoc E, Kiris A, et al. Sonographic measurement of the fetal cerebellum, cisternamagna, and cavum septum pellucidum in normal fetuses in the second and third trimesters of pregnancy[J]. Clin Ultrasound, 2003, 31(4): 194-200. [8]宋伊丽，李薇薇. 650例胎儿透明隔腔的超声测量[J]. 中华超声影像学杂志，2008，9（2）：180-182. [9]Cooper S. Prenatal abnormal width of the cavum septum pellucidum-MRI features and neurodevelopmental outcome[J]. Matern Neonatal Med, 2018, 31(22): 3043-3050. [10]兰为顺，夏薇，刘芳，等. 胎儿胼胝体缺如产前超声及磁共振诊断的应用分析[J]. 中华医学超声杂志：电子版，2015，12（5）：374-378. [11]Webb EA, Dattani MT. Septo-optic dysplasia[J]. Eur J Hum Genet, 2010, 18(4): 393-397. [12]田路. 视-隔发育不良的MRI表现[J]. 实用医技杂志，2006，13（4）：518-519. [13]Dubourg C, Bendavid C, Pasquier L, et al. Holoprosencephaly[J]. Orphanet J Rare Dis, 2007, 2(1): 8. [14]Matsunaga E, Shiota K, Holoprosencephaly in human embryos: epidemiologic studies of 150 cases[J]. Teratology, 1977, 16(3): 261-272. [15]Hahn JS, Barnes PD. Neuroimaging advances in holoprosencephaly: Refining the spectrum of the midline malformation[J]. Am J Med Genet CSemin Med Genet, 2010, 154(1): 120-132. [16]毛齐心，曹和涛，贺新华. 脑裂畸形的CT、MRI诊断[J]. 罕少疾病杂志，2011，18（5）：12-15. [17]Barkovich AJ, Norman D. Absence of the septum pellucidum: a useful sign in the diagnosis of congenital brain malformations[J]. AJR, 1989, 152(2): 353-360. [18]李经伦，向淑利，李小刚. 孔洞脑7例临床分析[J]. 华西医学，2008，23（5）：1121-1122. [19]马红艳. 超声诊断胎儿孔洞脑1例[J]. 中国超声医学杂志，2010，26（11）：1037.