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| Genes associated with white matter microstructure abnormality in schizophrenia |
| YANG Bing-bing1, ZHANG Xue1, ZHUO Chuan-jun2, LIU Feng1, QIN Wen1, YU Chun-shui1 |
| 1. Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China;
2. Department of Psychiatry Functional Neuroimaging Laboratory, Tianjin Anding Hospital, Tianjin 300070, China |
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Abstract Objective: To investigate the mean kurtosis(MK) changes in patients with schizophrenia and to analyze correlation of gene expression level with MK in order to explore genes associated with white matter microstructure abnormality in schizophrenia. Methods: Ninety-four schizophrenia patients and 91 healthy controls were recruited to undergo a diffusion kurtosis imaging(DKI). Subsequently, quantitative map of MK for each subject was calculated. MK difference between patients with schizophrenia and healthy controls was compared using voxel-based analysis(VBA). For each brain tissue sample, expression profiles of 196 schizophrenia risk genes were extracted from six donated brains of the Allen Human Brain Atlas(AHBA). Genes associated with MK change in schizophrenia were identified by performing sample-wise spatial correlations between expression levels of each gene and case-control MK difference. Results: Relative to healthy controls, patients with schizophrenia had decreased MK mainly in the white matter of prefrontal lobe, corona radiata, internal capsule and corpus callosum. We found that expression levels of 16 genes had showed significant sample-wise spatial correlations with MK changes in schizophrenia. These genes were functionally enriched for calcium ion homeostasis and transmembrane transport, inositol trisphosphate metabolic process and cell-cell junction. Conclusion: This study provides a set of genes possibly associated with MK change in schizophrenia, which could be used as candidate genes to explore biological mechanisms underlying the structural impairments of white matter in schizophrenia.
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Received: 17 March 2020
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