18F-FDG PET/CT显像在乳腺外Paget病中的临床应用

doi:10.12117/jccmi.2020.08.015

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Abstract Objective: To investigate the role of 18F-FDG PET/CT in the diagnosis, staging and follow-up of extramammary Paget’s disease(EMPD). Methods: Whole-body 18F-FDG PET/CT images of 13 patients with newly diagnosed or suspected recurrent EMPD were retrospectively analyzed. The lesions with increased uptake of 18F-FDG were positive and were measured with maximum standard uptake(SUVmax). Results: Among the 13 patients with EMPD, 11 received 18F-FDG PET/CT before surgery and 2 received 18F-FDG PET/CT after surgery. Eleven patients had skin lesions, 18F-FDG uptake of all skin lesions was increased in varying degrees, SUVmax ranged from 1.4 to 15.9. The skin lesions thickness was more than or equal to 1 cm in 4 cases(4/11), and SUVmax ranged from 4.6 to 15.9, the thickness was less than 1 cm in 7 cases(7/11), and SUVmax ranged from 1.4 to 3.9. The SUVmax of skin lesions between two groups was compared by independent sample t-test and the results showed that t=2.821, P=0.064, without statistical significance. Lymph node metastasis was found in 7(7/13), and SUVmax ranged from 3.4 to 15.1, and one of them(1/7) was suspected recurrence after EMPD surgery and radiotherapy. In 13 EMPD patients, distant metastasis was found in 2 cases(1 case with single bony metastasis, 1 case with multiple lung, liver and bone metastases), all lesions showed increased FDG uptake in varying degrees and SUVmax ranged from 3.8 to 14.0. Two cases(2/13) of EMPD with lung cancer or colon cancer were found. Conclusion: 18F-FDG PET/CT diagnosis of EMPD mainly depends on the thickness of the lesion, which is more sensitive to the diagnosis of metastasis. Therefore, 18F-FDG PET/CT is very useful for the diagnosis, staging and follow-up of EMPD.

Key words： Skin neoplasms Fluorodeoxyglucose F18 Positron-emission tomography

Received: 07 January 2020

PACS:	Ｒ739.5
	Ｒ817.4

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	Articles by authors
	LIU Wei-kun
	ZHOU Xuan
	PENG Li
	WANG Peng-long
	DUAN Yu-jiao
	CHENG Lei
	YIN Ji-lin

Cite this article:

LIU Wei-kun,ZHOU Xuan,PENG Li, et al. Clinical application of 18F-FDG PET/CT in extramammary Paget’s disease[J]. JOURNAL OF CHINA MEDICAL IMAGING, 2020, 31(8): 588-591.

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http://www.jccmi.com.cn/EN/10.12117/jccmi.2020.08.015 OR http://www.jccmi.com.cn/EN/Y2020/V31/I8/588

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