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| C-erbB-2, MVD expression in ovarian tumors and their relationship to the blood flow of CPA |
| JIN Rong1, LI Yan-min1, CUI Zhuang2, JIAO Tong1, GAO Wei-ping2 |
| 1. The First Central Hospital of Tianjin, Tianjin 300192, China; 2. Tianjin Medical University, Tianjin 300074, China |
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Abstract Objective: To evaluate the relationship between C-erbB-2, MVD expressions in ovarian tumors and the blood flow of CPA. Methods: Fifty cases of ovarian tumors were examined preoperatively by CPA whereas C-erbB-2 and MVD were stained with immunohistochemistry after operation. Results: The positive expression rate of C-erbB-2 in malignant ovarian tumors was 83.33% which was higher than that in the benign group(30%, P<0.05), the MVD value of malignant ovarian tumors showed positive correlation to the degree of CPA(r=0.823, P<0.05), the MVD value(53.37±7.91) in the positive C-erbB-2 groups including benign and malignant ovarian tumors was higher than that in negative C-erbB-2 group(38.93±3.19, P<0.05). MVD in the malignant ovarian tumors(48.84±6.19) was higher than that in the benign group(20.90±2.71, P<0.05). Their MVD demonstrated a positive correlation to the degree of CPA. The RI value of malignant group(0.36±0.06) was significantly lower than that of the benign group(0.68±0.07, P<0.05). RI values and MVD showed negative correlation(r=-0.806, P<0.05). Conclusion: The expressions of C-erbB-2 and MVD for ovarian tumors support CPA pathologically and the latter provides in turn the sensitive blood flow information for diagnosis of benign and malignant ovarian tumors in clinic.
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Received: 17 March 2006
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2006, Vol. 17 
