|
|
|
| Study of relationship between fluid shear rate and atherosclerotic plaque in abdominal aorta in model rabbits |
| CHEN Xiang-hua, FENG Xiang-fei, TANG Zheng-de, SHENG Jing, CHEN Chao-ting |
| The Ninth Affiliated People’s Hospital of Shanghai Second Medical University, Shanghai 200011, China |
|
|
|
|
Abstract Objective: To investigate the roles of fluid shear rate(SRs) on atherosclerotic plaques in model rabbits through Doppler ultrasound imaging technique. Methods: The atherosclerotic plaques were made in 29 rabbits by undergoing balloon-induced abdominal aorta wall injury and then fed on a diet of high cholesterol. The parameters such as: intima-medial thickness(IMT), average image intensity correction(AIIc%), systolic velocity(Vs), systolic diameter of lumen(Ds) and so on were measured with ultrasound imaging before a diet of high cholesterol and half month, one month, two months, three months and four months after abdominal aorta wall injured. Then SRs was calculated as well. Results: IMT became thicker and thicker. After abdominal aorta wall injured, the SRs first became low and then high, finally became low. The values of SRs after abdominal aorta wall injured were different with that before a diet of high cholesterol(P<0.05). Conclusions: IMT, AIIc% were significantly related to the thickness of atherosclerotic plaques. Lower SRs was one of the factors important in the shaping of atheros-clerotic plaques, but higher SRs may make atherosclerotic plaques unstable.
|
|
Received: 21 September 2005
|
|
|
|
|
|
|
|
|
2006, Vol. 17 
