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| Comparative study of 18F-FDG PET/CT and CT in evaluating curative effect of breast cancer |
| SUN Lin, GAO Zai-rong, ZHANG Yong-xue, JIA Qing, WU Zhi-jian, CHANG Wei |
| Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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Abstract Objective: To evaluate the use of 18F-fluorodeoxyglucose(FDG) PET/CT in recurrence and metastasis of breast cancer. Methods: Thirty-seven patients after operation underwent 18F-FDG PET/CT whole body imaging for evaluation of recurrent breast cancer and metastasis. Visual and semiquantitative methods(standard uptake value, SUV) were used to analyze the images. The results of PET/CT imaging were compared with those of pathology or CT. Results: Twenty-seven malignant recurrent breast lesions in thirty-seven resected breast cancers detected by this modality were proven histopathology, biopsy, cytological examination, and clinical follow-up. Among the twenty-seven malignant breast lesions, the diagnostic sensitivity of PET/CT and CT imaging were 96.30% and 62.96% respectively. There were statistical differences in sensitivity between PET/CT and CT(χ2=9.247, P<0.05). Fourteen patients with breast cancer underwent PET/CT at 2 time points. Recurrence and metastasis were diagnosed in 9 patients, and all of their SUVs increased at time 2. Conclusions: 18F-FDG PET/CT makes the location and characterization of the lesions more accurate, and it is a useful diagnostic modality in the diagnosis of recurrent and metastatic breast cancer.
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Received: 18 June 2007
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Corresponding Authors:
GAO Zai-rong
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2007, Vol. 18 
