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| Relationship between 18F-FDG uptake and the factors influence the standardized uptake value of breast cancer |
| LI Xue-na, YIN Ya-fu, LI Ya-ming |
| Department of Nuclear Medicine, First Affiliated Hospital, China Medical University, Shenyang 110001, China |
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Abstract Objective: To evaluate the effect of age, size of foci, the CT value of foci, serum glucose level, menopausal status on the 18F-FDG uptake in normal breast tissue and breast cancer by quantitative standardized uptake values(SUV). Methods: Twenty-seven patients(premenopausal 13; postmenopausal 14) highly suspected of breast cancer underwent FDG PET/CT imaging. The semi-quantitative analysis methods of FDG uptake were used. We analyzed for contralateral normal breast tissue. To analyze the correlations between the SUVmax and age, size, the CT value, menopausal status. Results: Thirty-two breast lesions were found in operation and all were confirmed histologically. Of the 32 lesions, 25 were malignant and 7 benign. SUVmax of malignant lesion, benign lesion and contralateral normal breast tissue were 5.08±3.55, 1.17±0.31, 0.76±0.52, respectively. The SUV of malignant lesion was significantly higher than those of contralateral normal breast and benign lesion(all P<0.01). There was no significant difference between benign lesion and normal breast in SUV(P>0.05). Significant correlation of breast disease was found between the SUVmax and age, size. There was no correlations between SUVmax and size of foci, the CT value or menopausal status. There were no significant correlations of normal breast tissue between them. Conclusions: The age and size of breast disease have significant effect on SUV of 18F-FDG uptake. 18F-FDG PET is a reliable method in differentiating malignant and benign lesions of the breast.
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Received: 11 October 2007
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Corresponding Authors:
LI Ya-ming
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2007, Vol. 18 
