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| Synthetic methods research of 18F-FDG as phase-transfer calalyst by ionic liquid with one step methodology |
| XIN Jun1, LI Hong-li2, GUO Qi-yong1, ZHAO Zhou-she2, ZHOU Tong1, LI Yun-tao1 |
| 1.Department of Radiology, Shengjing Hospital of Chinese Medical University, Shenyang 110004, China;2.GE Healthcare China, Beijing 100176, China |
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Abstract Objective: To develop the new synthetic 18F-FDG method used ionic liquid(IL) as Phase transfer catalyst(PTC). Material and Method: Study the productivity of 18F-FDG with different volume (K2CO3, IL, acetonitrile). 1,3,4,6-tetra-O-acetyl-2-O-trifluromethanesulfonyl-D-mannopyanose(TATM) 25mg precursor and 1-Butyl-3-methylimidazolium trifluoromethanesulfonate(BMI) as PTC. Results: we got the highest 18F-FDG productivity(55%) and radiochemistry purity(93%) with 0.2ml K2CO3, 0.3ml BMI, 0.7ml acetonitrile and TATM 25mg. Conclusion: we can get the highest 18F-FDG productivity used BMI as PTC with TATM precursor.
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Received: 15 March 2007
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2007, Vol. 18 
