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| Experimental study of correlation between 18F-FDG metabolic imaging and expression of HIF-1α in breast carcinoma |
| SONG Wu-zhan1, CHI Jun1, WANG Jing2 |
| 1. Kunming General Hospital of Chengdu Military Commanding Region, Kunming 650032, China;2. Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China |
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Abstract Objective: To study the 18F-FDG metabolic imaging in breast carcinoma and the correlation between 18F-FDG uptake and the expression of HIF-1α. Method: Thirty-one patients with primary breast carcinoma diagnosed by fine needle aspiration underwent 18F-FDG metabolic imaging. Regions of interest(ROI) were drawn on the tumor(T) and contralateral normal breast tissue(NT), T/NT ratios were measured for all scans. The expression of HIF-1α was detected by immunohistochemical method. Results: In all 31 patients, 18F-FDG uptake of tumor tissue was obviously higher than that of normal tissue. The T/NT ratios of 31 tumors was 2.98±1.09, and have no relevance to the tumor size(P>0.05). Forty minutes after injecting 18F-FDG, the T/NT ratios of IDC(infiltrating ductal carcinoma) and ILC(infiltrating lobular carcinoma) were 2.98±0.97 and 2.96±1.45(P>0.05). In all 31 patients T/NT ratios ranged from 1.68 to 6.49(median: 2.73). The percentage of tumor cells expressing HIF-1α was 25.6%~78.5%(median: 56.3%), and a positive correlation was found between them(P<0.01). Conclusions: The tissue of breast carcinoma can uptake 18F-FDG obviously and has no relevance to pathologic type and tumor size, but expresses a positive correlation with HIF-1α.
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Received: 25 February 2007
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2007, Vol. 18 
