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| Comparative study with double-phase 99Tcm-MIBI tomographic imaging and mammography in diagnosis of breast lesions |
| CHEN Zai-jun, LIANG Qing-mo, ZHENG Zi-gui, BAO Zheng, XU Xian-hua, GUI Wen-lai, LUO Mao-xiang |
| The Affiliated Nanhua Hospital, Nanhua University, Hengyang Hunan 421002, China |
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Abstract Objective: To evaluate the value of double-phase 99Tcm-MIBI tomographic imaging and mammography in diagnosis of breast lesions. Methods: Double-phase 99Tcm-MIBI tomographic imaging and mammography were performed within one week for patients with breast neoplasms. The final diagnosis were verified with histological examination. Result: ①The T/NT ratios of early and delayed imaging were 2.08±2.85 and 1.69±3.05 in benign lesions. There was significant difference(P<0.05). The T/NT ratios of early and delayed imaging were 5.00±4.34 and 6.79±11.94 in malignant tumors, there was no significant difference(P>0.05). ②The sensitivity of double-phase 99Tcm-MIBI tomographic imaging in diagnosis of breast cancer was 97.1%; specificity was 94.8%; accuracy was 95.7%; the positive predictive value was 91.9%, and the negative predictive value was 98.2%. The sensitivity of mammography in diagnosis of breast cancer was 82.9% and specificity 70.7% and accuracy 75.3% and the positive predictive value 63.0% and the negative predictive value 87.2%, the two methods showed significant difference(P<0.05). Conclusion: The double-phase 99Tcm-MIBI tomographic imaging is superior to the mammography in diagnosing breast cancer, double-phase 99Tcm-MIBI tomographic imaging has higher sensitivity and specificity in the diagnosis of breast cancer. It is an effective means in differentiating benign from malignant lesions.
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Received: 21 March 2007
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2007, Vol. 18 
