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| Correlation study between Cho/Cr value of MRS and Ki-67 labeling index in meningiomas |
| SHI Rui-hua, ZHAI Ren-you, QIAN Xiao-jun, LU Wan-hong, GU Hua |
| Department of Radiology, Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China |
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Abstract Objective: To investigate the correlation between Cho/Cr value of 1H magnetic resonance spectroscopy(1H-MRS) and the Ki-67 labeling index in meningiomas. Methods: Thirty-six patients with meningioma underwent conventional MR and 1H-MRS before operation(Grade I 30 cases; Grade II+III 6 cases). 1H-MRS sequences included PRESS 35, PRESS 144. Expression of Ki-67 nuclear antigen were detected by immunohistochemical method of streptavidin-biotin-peroxidase(SP). Results: The mean Cho/Cr ratio in the benign and malignant groups were 3.80±1.08 and 7.22±0.70, respectively(t=7.40, P=0.000）. Ki-67 in the benign and malignant groups were 6.43±1.09 and 12.15±4.14, respectively. A significant linear correlation was observed between the Cho/Cr ratio and the expression of Ki-67. The MRS features of meningiomas were as follow: Cho increased markedly, Cr decreased evidently. Conclusion: 1H-MRS is a useful diagnostic method for determining the proliferation or malignant potential of meningiomas according to the Cho/Cr ratio and the latter is correlated to the Ki-67 value.
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Received: 07 May 2008
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2008, Vol. 19 
