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| Application of 18F-FDG PET/CT in patients with biopsy proven tumor metastases from unknown primary site |
| ZHENG Rong, WU Ning, LI Jing, ZHANG Wen-jie, LIU Ying, ZHAO Ping |
| PET-CT Center, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China |
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Abstract Objective: To evaluate the role of whole body PET/CT scan with (18)F-fluorodeoxyglucose(FDG) in the detection of the primary tumor in patients with metastatic cancer from unknown primary origin. Methods: Fifty-four consecutive patients, with biopsy proven tumor metastases from unknown primary site, underwent a whole-body FDG-PET/CT study. Results: The primary tumor site was correctly identified by FDG-PET/CT in 41 patients(41/54, 75.9%). In 13 patients(13/54, 24.1%), the primary tumor site was not localized. However, in 35 cases(35/54, 64.8%) of them, FDG-PET/CT scan identified further unexpected metastases, modifying the stage of disease. Conclusion: Our data strongly support that the whole body FDG-PET/CT is a useful tool in the evaluation of patients with cancer with unknown primary site and PET/CT is able to find more metastatic lesions.
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Received: 18 November 2007
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2008, Vol. 19 
