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| Clinical application of multivoxel 1H-MRS in the peri-enhancement area of cerebral gliomas |
| HU Li-juan, LI Yang-bin |
| Department of Radiology, the Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China |
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Abstract Objective: To investigate the predictive value of multivoxel proton magnetic resonance spectroscopy(1H-MRS) in discussing the metabolic changes in peri-enhancement area of brain gliomas. To evaluate the role of MRS in determining the boundary of gliomas. Methods: Twenty-four cases with glioma confirmed by pathology were studied. According to the WHO diagnostic criteria, all cases were categorized into two groups, low grade gliomas(grade I, II) and high grade gliomas(grade III, IV). According to MRI manifestations, all cases were categorized into two groups(peritumoral edema and non-edema groups)． All of them underwent 1H-MRS examination before operation. The variety of metabolite peaks were detected in different areas. Results: ①Significant differences were found in the ratios of Cho/Cr, NAA/Cho and NAA/Cr between peri-enhancement areas of low grade gliomas and normal brain tissues(P<0.05). Significant differences were found in the ratios of Cho/Cr and NAA/Cho between peri-enhancement areas of high grade gliomas and normal brain tissues(P<0.05), but there were no significant differences in the ratios of NAA/Cr(P>0.05). There were no significant differences in the ratios of Cho/Cr, NAA/Cho and NAA/Cr in the peri-enhancement areas of low grade gliomas and high grade gliomas(P>0.05). ②Significant differences were found in the ratios of Cho/Cr, NAA/Cho and NAA/Cr(P<0.05) in peritumoral edema regions and normal tissue in contralateral hemispheres． Significant differences were found in the ratios of Cho/Cr, NAA/Cho(P<0.05) between peritumoral non-edema regions and normal tissue in contralateral hemispheres, but not in the ratios of NAA/Cr(P>0.05)． There were no significant differences in the ratios of Cho/Cr, NAA/Cho and NAA/Cr in the peritumoral edema and non-edema groups(P>0.05). Conclusion: Multivoxel proton magnetic spectroscopy(1H-MRS) will be useful in defining the border of brain glioma.
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Received: 28 January 2008
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2008, Vol. 19 
