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| Relative study on ventricular asynchrony and left ventricular function in experimental acute myocardial ischemia of canines |
| LIN Ping, LIU Chang-hong, JIANG Yan-na, WU Jun, ZHAO Yang |
| The Second Affiliated Hospital of Dalian Medical University, Dalian Liaoning 116027, China |
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Abstract Objective: To evaluate the relationship between ventricular asynchrony and left ventricular function in acute myocardial ischemia of canines. Quantitative tissue velocity imaging(QTVI) was used. Methods: Twenty-one canines were studied on QTVI, left coronary artery(LCA) was carefully dissected and occluded. Before LCA occlusion, the canines were defined as the normal control group and after occlusion defined as the experimental group. The regional velocity profiles in 12 segments of left ventricle(LV) were obtained. The time from onset of QRS to peak velocity during systole and early diastole(Ts and Te) were measured. The maximal difference in Ts and Te within the same wall(Intra-△Ts and Intra-△Te) and all 12 segments(Max-△Ts and Max-△Te) of the LV were calculated. The time from onset of QRS to beginning time of flow velocity spectra in aortic valve(Q-A) and pulmonary value(Q-P) and their differences(Q-AP) were measured. The parameters of LV pump function include the left ventricular ejection fraction(LVEF) and Tei index were calculated. Results: Intra-△Ts, Intra-△Te, Max-△Ts, Max-△Te, Q-A, Q-P and Q-AP were significantly prolonged compared with the control group. Max-△Ts was positively correlated with Tei index(P＜0.05) and negatively with LVEF(P＜0.05), Max-△Te was positively correlated with QRS duration(P＜0.05). Conclusions: The inter- and intraventricular asynchrony exists in canines with acute left ventricular ischemia and it has relation with LV function.
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Received: 13 March 2009
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2009, Vol. 20 
