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| Clinical research of dual source CT perfusion imaging in evaluating biological behavior of gastric carcinoma |
| LI Chun-zhi, XU Rong-tian, LI Xiang, JIN Yin-hua |
| Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China |
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Abstract Objective: To discuss the value of dual source CT perfusion imaging parameters in evaluating the biological behavior of gastric carcinoma. Materials and Methods: The perfusion parameters were obtained from patients who experienced the dual source CT scan. And they were divided into several groups according to the extent of cell differentiation of tumor after operation, invasive depths in the gastric wall and whether generating lymph node metastasis. Results: The BF and BV value in the distant metastasis and in the recent distant metastasis as well as the recent distant metastasis group were higher than that of no distant metastasis, meanwhile the evident difference was observed, P＜0.05(F=6.555, 5.972). Besides, the value of Patlak P in the muscularis infiltration group was lower than that in the serosa external group and it had significant difference, P＜0.05(F=5.460). And we concluded that PBV value was negatively correlated to the degree of cell differentiation, besides, positive correlation was observed between BV, BF, Patlak P, PBV value and invasive depths and the extent of distant metastasis. Besides, there were the positive relationship between BV, BF, Patlak P value and distant metastasis. Similarly, Patlak P value was positive related to the degree of lymph node metastasis. Conclusions: The dual source CT perfusion imaging parameters were able to demonstrate biological behaviors of gastric carcinoma. BF and BV value could evaluate distant metastasis and recent distant metastasis after operation or not objectively. Similarly, BV and Patlak P values were able to estimate the depth of the cancer tissue infiltrating the gastric wall objectively.
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Received: 10 May 2009
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Corresponding Authors:
中国医科大学附属第一医院放射科，110001。
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2009, Vol. 20 
