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| Comparison of the value of ultrasonic E-Tracking imaging and the method of flow-mediated vasodilation in evaluating vascular endothelial function in type 2 diabetes mellitus |
| HU Li-jun, LV Qing, MA Hong, WANG Xin-fang, LIAO Yun-fei, YU Fan |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laborary of Molecular Imaging, Wuhan 430022, China |
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Abstract Abstract: Objective: To study the value of ultrasonic E-Tracking imaging technology and the method of flow-mediated vasodilation in evaluating vascular endothelial function in type 2 diabetes mellitus(T2DM) comparatively. Methods: Forty-six T2DM and thirty normal controls were included. E-Tracking imaging technology was performed to follow the movement tracks of the right brachial arterial wall, parameters including internal systolic diameter(Ds), internal diastolic diameter(Dd), stiffness parameters(β), pressure-strain elastic modulus(Eρ), arterial compliance(AC), and one-point pulse wave velocity(PWVβ) were assessed. The dilation of brachial artery during reactive hyperaemia(with increased flow causing endothelium-dependent dilatation) and after sublingual nitroglycerin application NTG, causing endothelium-independent dilatation were measured using high resolution ultrasound. The same parameters were assessed after three months treatment with melbine in 24 cases of T2DM. Results: In the T2DM group, β, Eρ and PWVβ were significantly higher, and AC was significantly lower than those in the control group(P<0.01, comparatively). In T2DM, flow-mediated dilatation(FMD) decreased conspicuously compared with that in controls(P<0.01). The dilation by NTG was not significantly different between the two groups(P>0.05). Conclusion: E-Tracking imaging technology and the method of FMD can be used to evaluate vascular endothelial function in T2DM. Two methods have satisfactory concordance.
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Received: 17 September 2008
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2009, Vol. 20 
