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| Value of ADC and EDC at 3.0T in predicting hemorrhagic transformation after acute experimental cerebral infarction |
QUAN Guan-min1, YUAN Tao1, WEI Zhi-gang2, LIU Huai-jun1, SHANG Hua1,
GAO Guo-dong1, LEI Jian-ming1, LI Cai-ying1, GENG Zuo-jun1 |
| 1. Department of Radiology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;2. Department of Radiology, Shunping County Hospital, Shunping Hebei 072250, China |
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Abstract Objective: To investigate the value of diffusion weighted imaging(DWI) in predicting the hemorrhagic transformation(HT) after acute experimental cerebral infarction. Methods: Autologous thrombus was injected into unilateral internal carotid arteries of 75 rabbits to set up acute cerebral infarction model. These rabbits underwent DWI with 3.0T MR equipment at 3, 6, 12, 24, 48 and 72h after arterial occlusion. Apparent diffusion coefficient(ADC) and exponent diffusion coefficient(EDC) map were calculated at work station by using software of function. According to the method of European cooperative acute stroke study(ECASS), the HT of infarcted animals were classified into non-HT and HT groups, the latter was further divided into hemorrhagic infarction(HI) group and parenchymal hematoma(PH) group. The difference of ADC and EDC between non-HT group and various HT groups were assessed by using SPSS 11.5 software. Results: Cerebral ischemic model was successfully set up in 59 rabbits(78.67%). No pathologic findings of HT was found in 21 animals(35.59%, 21/59). Thirty-eight rabbits(64.41%, 38/59) who had HT included 31 rabbits(52.54%, 31/59) with HI and 7(11.87%, 7/59) with PH. The ADC value of non-HT groups and HT group were (0.601±0.128)×10-3~(0.813±0.060)×10-3 and (0.432±0.091)×10-3~(0.618±0.060)×10-3 respectively. There was obvious difference of ADC value between the two groups from 3h to 72h after occlusion(t=2.417~5.986, P=0.000~0.031). Similarly, significant difference of EDC value was found between the non-HT group[(0.415±0.039)~(0.502±0.009)] and HT rabbits[(0.559±0.040)~(0.583±0.064)](t=4.002~6.995, P=0.000~0.002). However, no obvious difference of ADC value was detected between HI group[(0.435±0.091)×10-3~(0.631±0.045)×10-3] and PH group[(0.390±0.180)×10-3~(0.586±0.104)×10-3](t=0.057~1.996, P=0.171~0.956) at every time point, except at 24h(t=4.664, P=0.002). There was no prominent difference of EDC value between HI[(0.545±0.039)~(0.638±0.042)] and PH groups[(0.575±0.054)~(0.649±0.019)](t=0.051~1.698, P=0.150~0.960). Conclusion: There is correlation between the decrease of ADC, the increase of EDC and the occurrence of HT in acute cerebral infarction. The abnormalities of ADC and EDC can probably predict HT. But DWI may play little role in the discrimination between HI and PH.
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Received: 02 September 2008
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2009, Vol. 20 
