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| Influences on bone mineral density and biochemical markers in patients with idiopathic hypercalciuria |
| ZHANG Si-wei, WANG Yi-ming, YOU Yu-mei |
| Department of Medical Imaging, Er-sha Branch of Guangdong Provincial Hospital of TCM, Guangzhou 510105, China |
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Abstract Objective: To evaluate the effects of different subtypes of idiopathic hypercalciuria(IH) on bone metabolism. Methods: Using dual-energy X-ray absorptiometry, bone mineral density(BMD) in lumbar spine and left femur were measured in 72 patients with IH and 72 age, sex and body weight index matched healthy persons. Biochemical markers of bone metabolism were also measured in all subjects. Results: In comparison to the control group, the patients with IH had significantly higher urinary Ca/Cr and DPD/Cr levels(P<0.01), and serum BALP, PTH and BGP levels were significantly higher in renal IH patients(P<0.05), whereas there was no significant difference between absorptive IH group and control group in serum BALP, PTH and BGP levels. Renal IH patients had significantly lower femoral neck BMD and lumbar spine BMD values when compared with control subjects. There was a significant negative correlation between BMD in different sites and the serum BALP, BGP and urinary DPD levels. Conclusion: Patients with renal lithiasis should be evaluated for IH. Osteopenia and disorder of bone metabolism are common in patients with IH, and monitoring the BMD and biochemical markers of bone is beneficial to early detection of such abnormalities for those patients.
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Received: 29 December 2008
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2009, Vol. 20 
